Cell Death Antibodies 1
Anti-CSNK2A2 Antibody (CAB13481)
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- SKU:
- CAB13481
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-CSNK2A2 Antibody |
| Antibody SKU: | CAB13481 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human CSNK2A2 (NP_001887.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | K-562, Mouse testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human CSNK2A2 (NP_001887.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPGP AAGS RARV YAEV NSLR SREY WDYE AHVP SWGN QDDY QLVR KLGR GKYS EVFE AINI TNNE RVVV KILK PVKK KKIK REVK ILEN LRGG TNII KLID TVKD PVSK TPAL VFEY INNT DFKQ LYQI LTDF DIRF YMYE LLKA LDYC HSKG IMHR DVKP HNVM IDHQ QKKL RLID WGLA EFYH PAQE YNVR VASR YFKG PELL VDYQ MYDY SLDM WSLG CMLA SMIF RREP FFHG QDNY DQLV RIAK VLGT EELY GYLK KYHI DLDP HFND ILGQ HSRK RWEN FIHS ENRH LVSP EALD LLDK LLRY DHQQ RLTA KEAM EHPY FYPV VKEQ SQPC ADNA VLSS GLTA AR |
| Gene ID: | 1459 |
| Uniprot: | P19784 |
| Cellular Location: | |
| Calculated MW: | 41kDa |
| Observed MW: | 38kDa |
| Synonyms: | CSNK2A2, CK2A2, CK2alpha, CSNK2A1 |
| Background: |
| UniProt Protein Function: | CK2A2: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily. |
| UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; CK2 family Chromosomal Location of Human Ortholog: 16q21 Cellular Component: PcG protein complex; nucleus; cytosol Molecular Function:protein serine/threonine kinase activity; protein binding; protein N-terminus binding; ATP binding Biological Process: axon guidance; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptosis; mitotic cell cycle; protein amino acid phosphorylation |
| NCBI Summary: | This gene encodes the alpha', or alpha 2, catalytic subunit of the protein kinase enzyme, casein kinase 2 (CK2). Casein kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. This heterotetrameric kinase includes two catalytic subunits, either alpha or alpha', and two regulatory beta subunits. The closely related gene paralog encoding the alpha, or alpha 1 subunit (CSNK2A1, Gene ID: 1457) is found on chromosome 20. An intronic variant in this gene (alpha 2) may be associated with leukocyte telomere length in a South Asian population. A related transcribed pseudogene is found on chromosome 11. [provided by RefSeq, Aug 2017] |
| UniProt Code: | P19784 |
| NCBI GenInfo Identifier: | 125266 |
| NCBI Gene ID: | 1459 |
| NCBI Accession: | P19784.1 |
| UniProt Related Accession: | P19784 |
| Molecular Weight: | |
| NCBI Full Name: | Casein kinase II subunit alpha' |
| NCBI Synonym Full Names: | casein kinase 2 alpha 2 |
| NCBI Official Symbol: | CSNK2A2 |
| NCBI Official Synonym Symbols: | CK2A2; CSNK2A1; CK2alpha' |
| NCBI Protein Information: | casein kinase II subunit alpha' |
| UniProt Protein Name: | Casein kinase II subunit alpha' |
| Protein Family: | Protein |
| UniProt Gene Name: | CSNK2A2 |
| UniProt Entry Name: | CSK22_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CSNK2A2 antibody (CAB13481) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded rat lung using CSNK2A2 antibody (CAB13481) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung cancer using CSNK2A2 antibody (CAB13481) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver cancer using CSNK2A2 antibody (CAB13481) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using CSNK2A2 antibody (CAB13481) at dilution of 1:100 (40x lens). |
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