Cell Biology Antibodies 3
Anti-CSN2 Antibody (CAB12749)
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- SKU:
- CAB12749
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CSN2 Antibody |
| Antibody SKU: | CAB12749 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CSN2 (NP_001882.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | MCF7 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CSN2 (NP_001882.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKVL ILAC LVAL ALAR ETIE SLSS SEES ITEY KQKV EKVK HEDQ QQGE DEHQ DKIY PSFQ PQPL IYPF VEPI PYGF LPQN ILPL AQPA VVLP VPQP EIME |
| Gene ID: | 1447 |
| Uniprot: | P05814 |
| Cellular Location: | Secreted |
| Calculated MW: | 25kDa |
| Observed MW: | 30kDa |
| Synonyms: | CSN2, CASB |
| Background: | This gene is a member of the beta casein family. There are two types of casein protein, beta (encoded by this gene) and kappa, both of which are secreted in human milk. Beta casein is the principal protein in human milk and the primary source of essential amino acids for a suckling infant. Beta and kappa casein proteins acting together form spherical micelles which bind within them important dietary minerals, such as calcium and phosphorous. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CSN2: Important role in determination of the surface properties of the casein micelles. Belongs to the beta-casein family. |
| UniProt Protein Details: | Protein type:Calcium-binding; Inhibitor; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 4q13.3 Cellular Component: extracellular region; extracellular space Molecular Function:calcium ion binding; cysteine protease inhibitor activity; enzyme inhibitor activity Biological Process: calcium ion transport; lactation |
| NCBI Summary: | This gene is a member of the beta casein family. There are two types of casein protein, beta (encoded by this gene) and kappa, both of which are secreted in human milk. Beta casein is the principal protein in human milk and the primary source of essential amino acids for a suckling infant. Beta and kappa casein proteins acting together form spherical micelles which bind within them important dietary minerals, such as calcium and phosphorous. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] |
| UniProt Code: | P05814 |
| NCBI GenInfo Identifier: | 115661 |
| NCBI Gene ID: | 1447 |
| NCBI Accession: | P05814.4 |
| UniProt Secondary Accession: | P05814,Q4VAZ9, Q9UCM5, |
| UniProt Related Accession: | P05814 |
| Molecular Weight: | 25kDa |
| NCBI Full Name: | Beta-casein |
| NCBI Synonym Full Names: | casein beta |
| NCBI Official Symbol: | CSN2 |
| NCBI Official Synonym Symbols: | CASB |
| NCBI Protein Information: | beta-casein |
| UniProt Protein Name: | Beta-casein |
| Protein Family: | COP9 signalosome complex |
| UniProt Gene Name: | CSN2 |
 | Western blot analysis of extracts of MCF7 cells, using CSN2 antibody (CAB12749) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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