Antibody Name:	Anti-CRYBB2 Mouse Monoclonal Antibody
Antibody SKU:	CAB14181
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Mouse, Rat
Host Species:	Mouse
Immunogen:	Recombinant protein of human CRYBB2

Application:	WB IHC
Recommended Dilution:	WB 1:200 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Mouse, Rat
Positive Samples:

Immunogen:	Recombinant protein of human CRYBB2
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	1415
Uniprot:	P43320
Cellular Location:
Calculated MW:	23kDa
Observed MW:	Refer to figures

Synonyms:

CRYBB2, CCA2, CRYB2, CRYB2A, CTRCT3, D22S665

Background:

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts.

UniProt Protein Function:	CRYBB2: a major structural protein of the eye lens. A member of the beta/gamma-crystallin family. Defects are the cause of congenital cerulean type 2 cataract, sutural cataract with punctate and cerulean opacities, and Coppock-like cataract.
UniProt Protein Details:	Chromosomal Location of Human Ortholog: 22q11.23 Molecular Function:identical protein binding; protein homodimerization activity; structural molecule activity; structural constituent of eye lens Biological Process: camera-type eye development; visual perception; response to stimulus Disease: Cataract 3, Multiple Types
NCBI Summary:	Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts. [provided by RefSeq, Jul 2008]
UniProt Code:	P43320
NCBI GenInfo Identifier:	1169091
NCBI Gene ID:	1415
NCBI Accession:	P43320.2
UniProt Secondary Accession:	P43320,Q9UCM8,
UniProt Related Accession:	P43320
Molecular Weight:	205
NCBI Full Name:	Beta-crystallin B2
NCBI Synonym Full Names:	crystallin, beta B2
NCBI Official Symbol:	CRYBB2
NCBI Official Synonym Symbols:	CCA2; CRYB2; CRYB2A; CTRCT3; D22S665
NCBI Protein Information:	beta-crystallin B2; beta-B2 crystallin; beta-crystallin Bp; eye lens structural protein
UniProt Protein Name:	Beta-crystallin B2
UniProt Synonym Protein Names:	Beta-B2 crystallin; Beta-crystallin Bp
Protein Family:	Beta-crystallin
UniProt Gene Name:	CRYBB2
UniProt Entry Name:	CRBB2_HUMAN