Signal Transduction Antibodies 1

Anti-CRIPT Antibody (CAB14336)

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SKU:
CAB14336
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-CRIPT Antibody
Antibody SKU:CAB14336
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-101 of human CRIPT (NP_054890.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse lung, Rat heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-101 of human CRIPT (NP_054890.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVCE KCEK KLGT VITP DTWK DGAR NTTE SGGR KLNE NKAL TSKK ARFD PYGK NKFS TCRI CKSS VHQP GSHY CQGC AYKK GICA MCGK KVLD TKNY KQTS V
Gene ID:9419
Uniprot:Q9P021
Cellular Location:Cell junction, Cell projection, Cytoplasm, dendritic spine, synapse
Calculated MW:11kDa
Observed MW:11kDa
Synonyms:CRIPT, HSPC139, SSMDF
Background:This gene encodes a protein that binds to the PDZ3 peptide recognition domain. The encoded protein may modulates protein interactions with the cytoskeleton. A mutation in this gene resulted in short stature with microcephaly and distinctive facies.
UniProt Protein Function:CRIPT: Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. Belongs to the CRIPT family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: cell soma; cytoplasm; postsynaptic density; dendrite; nucleolus; dendritic spine; dendritic shaft; nucleus; cell junction

Molecular Function:protein binding; microtubule binding; protein complex binding; PDZ domain binding

Biological Process: establishment of protein localization; cytoplasmic microtubule organization and biogenesis

Disease: Short Stature With Microcephaly And Distinctive Facies

NCBI Summary:This gene encodes a protein that binds to the PDZ3 peptide recognition domain. The encoded protein may modulates protein interactions with the cytoskeleton. A mutation in this gene resulted in short stature with microcephaly and distinctive facies. [provided by RefSeq, Jun 2014]
UniProt Code:Q9P021
NCBI GenInfo Identifier:7661798
NCBI Gene ID:9419
NCBI Accession:NP_054890.1
UniProt Related Accession:Q9P021
Molecular Weight:11,216 Da
NCBI Full Name:cysteine-rich PDZ-binding protein
NCBI Synonym Full Names:cysteine-rich PDZ-binding protein
NCBI Official Symbol:CRIPT  
NCBI Official Synonym Symbols:SSMDF; HSPC139  
NCBI Protein Information:cysteine-rich PDZ-binding protein; postsynaptic protein CRIPT; cysteine-rich interactor of PDZ3; cysteine-rich interactor of PDZ three
UniProt Protein Name:Cysteine-rich PDZ-binding protein
UniProt Synonym Protein Names:Cysteine-rich interactor of PDZ three; Cysteine-rich interactor of PDZ3
Protein Family:Cysteine-rich PDZ-binding protein
UniProt Gene Name:CRIPT  
UniProt Entry Name:CRIPT_HUMAN
Anti-CRIPT Antibody (CAB14336)Western blot analysis of extracts of various cell lines, using CRIPT antibody (CAB14336) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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