Cell Biology Antibodies 3
Anti-CRHBP Antibody (CAB13027)
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- SKU:
- CAB13027
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CRHBP Antibody |
| Antibody SKU: | CAB13027 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 221-322 of human CRHBP (NP_001873.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, LO2, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 221-322 of human CRHBP (NP_001873.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TLGH VNGL QLKK SSAG CEGI GDFV ELLG GTGL DPSK MTPL ADLC YPFH GPAQ MKVG CDNT VVRM VSSG KHVN RVTF EYRQ LEPY ELEN PNGN SIGE FCLS GL |
| Gene ID: | 1393 |
| Uniprot: | P24387 |
| Cellular Location: | Secreted |
| Calculated MW: | 36kDa |
| Observed MW: | 36kDa |
| Synonyms: | CRHBP, CRF-BP, CRFBP |
| Background: | Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. |
| UniProt Protein Function: | CRHBP: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Inhibitor; Secreted Chromosomal Location of Human Ortholog: 5q13.3 Cellular Component: dendrite; endoplasmic reticulum; extracellular space; Golgi apparatus; intracellular; microtubule; multivesicular body; nerve terminal; nucleus; perikaryon; secretory granule Molecular Function:corticotropin-releasing hormone binding; peptide binding; protein binding Biological Process: behavioral response to ethanol; cellular response to stress; female pregnancy; hormone-mediated signaling; inflammatory response; learning and/or memory; negative regulation of adrenocorticotropic hormone secretion; regulated secretory pathway; regulation of adrenocorticotropin hormone secretion; signal transduction; synaptic transmission, dopaminergic |
| NCBI Summary: | Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P24387 |
| NCBI GenInfo Identifier: | 544099 |
| NCBI Gene ID: | 1393 |
| NCBI Accession: | P24387.2 |
| UniProt Secondary Accession: | P24387,Q53F32, Q6FHT5, |
| UniProt Related Accession: | P24387 |
| Molecular Weight: | 36,144 Da |
| NCBI Full Name: | Corticotropin-releasing factor-binding protein |
| NCBI Synonym Full Names: | corticotropin releasing hormone binding protein |
| NCBI Official Symbol: | CRHBP |
| NCBI Official Synonym Symbols: | CRFBP; CRF-BP |
| NCBI Protein Information: | corticotropin-releasing factor-binding protein |
| UniProt Protein Name: | Corticotropin-releasing factor-binding protein |
| UniProt Synonym Protein Names: | Corticotropin-releasing hormone-binding protein; CRH-BP |
| Protein Family: | Corticotropin-releasing factor-binding protein |
| UniProt Gene Name: | CRHBP |
| UniProt Entry Name: | CRHBP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CRHBP antibody (CAB13027) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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