Developmental Biology
Anti-CREG1 Antibody (CAB16081)
- SKU:
- CAB16081
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-CREG1 Antibody |
| Antibody SKU: | CAB16081 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-190 of human CREG1 (NP_003842.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | mouse liver, rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-190 of human CREG1 (NP_003842.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LQLS VSNL QENP YATL TMTL AQTN FCKK HGFD PQSP LCVH IMLS GTVT KVNE TEMD IAKH SLFI RHPE MKTW PSSH NWFF A |
| Gene ID: | 8804 |
| Uniprot: | O75629 |
| Cellular Location: | Secreted |
| Calculated MW: | 24kDa |
| Observed MW: | 30kDa |
| Synonyms: | CREG1, CREG |
| Background: | The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. |
| UniProt Protein Function: | CREG1: May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R. Belongs to the CREG family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Transcription, coactivator/corepressor; Secreted Chromosomal Location of Human Ortholog: 1q24 Cellular Component: extracellular space Molecular Function:transcription corepressor activity Biological Process: cell proliferation; multicellular organismal development; regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75629 |
| NCBI GenInfo Identifier: | 59797902 |
| NCBI Gene ID: | 8804 |
| NCBI Accession: | O75629.1 |
| UniProt Secondary Accession: | O75629,Q8N9A3, B2RDD4, |
| UniProt Related Accession: | O75629 |
| Molecular Weight: | 24,075 Da |
| NCBI Full Name: | Protein CREG1 |
| NCBI Synonym Full Names: | cellular repressor of E1A stimulated genes 1 |
| NCBI Official Symbol: | CREG1 |
| NCBI Official Synonym Symbols: | CREG |
| NCBI Protein Information: | protein CREG1 |
| UniProt Protein Name: | Protein CREG1 |
| UniProt Synonym Protein Names: | Cellular repressor of E1A-stimulated genes 1 |
| Protein Family: | Protein |
| UniProt Gene Name: | CREG1 |
| UniProt Entry Name: | CREG1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CREG1 antibody (CAB16081) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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