Immunology Antibodies 1
Anti-CRACR2A Antibody (CAB13838)
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- SKU:
- CAB13838
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-CRACR2A Antibody |
| Antibody SKU: | CAB13838 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CRACR2A (NP_001138430.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CRACR2A (NP_001138430.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAP DGRV VSRP QRLG QGSG QGPK GSGA CLHP LDSL EQKE TQEQ TSGQ LVML RKAQ EFFQ TCDA EGKG FIAR KDMQ RLHK ELPL SLEE LEDV FDAL DADG NGYL TPQE FTTG FSHF FFSQ NNPS QEDA GEQV AQRH EEKV YLSR GDED LGDM GEDE EAQF RMLM DRLG AQKV LEDE SDVK QLWL QLKK EEPH LLSN FEDF |
| Gene ID: | 84766 |
| Uniprot: | Q9BSW2 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 45kDa/83kDa |
| Observed MW: | 45kDa |
| Synonyms: | CRACR2A, EFCAB4B |
| Background: |
| UniProt Protein Function: | EFCAB4B: Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. Belongs to the EFCAB4 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 12p13.32 Cellular Component: cytoplasm; Golgi apparatus; membrane; nucleolus; nucleus Molecular Function:calcium ion binding; protein binding Biological Process: activation of store-operated calcium channel activity; positive regulation of calcium ion transport |
| UniProt Code: | Q9BSW2 |
| NCBI GenInfo Identifier: | 74761240 |
| NCBI Gene ID: | 84766 |
| NCBI Accession: | Q9BSW2.1 |
| UniProt Secondary Accession: | Q9BSW2,B4E1X0, B9EK63, |
| UniProt Related Accession: | Q9BSW2 |
| Molecular Weight: | 83,193 Da |
| NCBI Full Name: | EF-hand calcium-binding domain-containing protein 4B |
| NCBI Synonym Full Names: | calcium release activated channel regulator 2A |
| NCBI Official Symbol: | CRACR2A |
| NCBI Official Synonym Symbols: | EFCAB4B |
| NCBI Protein Information: | EF-hand calcium-binding domain-containing protein 4B |
| UniProt Protein Name: | EF-hand calcium-binding domain-containing protein 4B |
| UniProt Synonym Protein Names: | Calcium release-activated calcium channel regulator 2A; CRAC channel regulator 2A; Calcium release-activated channel regulator 2A |
| Protein Family: | EF-hand calcium-binding domain-containing protein |
| UniProt Gene Name: | CRACR2A |
| UniProt Entry Name: | EFC4B_HUMAN |
 | Western blot analysis of extracts of mouse liver, using CRACR2A antibody (CAB13838) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human colon using CRACR2A antibody (CAB13838) at dilution of 1:150 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using CRACR2A antibody (CAB13838) at dilution of 1:150 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human appendix using CRACR2A antibody (CAB13838) at dilution of 1:150 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spleen using CRACR2A antibody (CAB13838) at dilution of 1:150 (40x lens). |
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