Signal Transduction Antibodies 3
Anti-CRABP2 Antibody (CAB6119)
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- SKU:
- CAB6119
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-CRABP2 Antibody |
| Antibody SKU: | CAB6119 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-94 of human CRABP2 (NP_001869.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:20 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, SW480, A-431, 22Rv1, HT-29, 293T, Mouse brain, Mouse uterus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-94 of human CRABP2 (NP_001869.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VLGV NVML RKIA VAAA SKPA VEIK QEGD TFYI KTST TVRT TEIN FKVG EEFE EQTV DGRP CKSL VKWE SENK M |
| Gene ID: | 1382 |
| Uniprot: | P29373 |
| Cellular Location: | Cytoplasm, Endoplasmic reticulum, Nucleus |
| Calculated MW: | 15kDa |
| Observed MW: | 15kDa |
| Synonyms: | CRABP2, CRABP-II, RBP6 |
| Background: | This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | CRABP2: Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: nucleoplasm; endoplasmic reticulum; cytoplasm; cytosol Molecular Function:retinoid binding; retinoic acid binding; transporter activity; retinal binding; retinol binding Biological Process: embryonic forelimb morphogenesis; epidermis development; regulation of transcription, DNA-dependent; retinoic acid metabolic process; signal transduction; transmembrane transport |
| NCBI Summary: | This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010] |
| UniProt Code: | P29373 |
| NCBI GenInfo Identifier: | 132401 |
| NCBI Gene ID: | 1382 |
| NCBI Accession: | P29373.2 |
| UniProt Secondary Accession: | P29373,Q6ICN6, B2R4Z8, D3DVC5, F1T098, |
| UniProt Related Accession: | P29373 |
| Molecular Weight: | 138 |
| NCBI Full Name: | Cellular retinoic acid-binding protein 2 |
| NCBI Synonym Full Names: | cellular retinoic acid binding protein 2 |
| NCBI Official Symbol: | CRABP2 |
| NCBI Official Synonym Symbols: | RBP6; CRABP-II |
| NCBI Protein Information: | cellular retinoic acid-binding protein 2; cellular retinoic acid-binding protein II |
| UniProt Protein Name: | Cellular retinoic acid-binding protein 2 |
| UniProt Synonym Protein Names: | Cellular retinoic acid-binding protein II; CRABP-II |
| Protein Family: | Cellular retinoic acid-binding protein |
| UniProt Gene Name: | CRABP2 |
| UniProt Entry Name: | RABP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CRABP2 antibody (CAB6119) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat brain using CRABP2 antibody (CAB6119) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using CRABP2 antibody (CAB6119). Blue: DAPI for nuclear staining. |
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