Developmental Biology
Anti-CPNE6 Antibody (CAB14385)
- SKU:
- CAB14385
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-CPNE6 Antibody |
| Antibody SKU: | CAB14385 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 268-557 of human CPNE6 (NP_006023.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 268-557 of human CPNE6 (NP_006023.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KYRD KKKN YKSS GTVV LAQC TVEK VHTF LDYI MGGC QISF TVAI DFTA SNGD PRSS QSLH CLSP RQPN HYLQ ALRA VGGI CQDY DSDK RFPA FGFG ARIP PNFE VSHD FAIN FDPE NPEC EEIS GVIA SYRR CLPQ IQLY GPTN VAPI INRV AEPA QREQ STGQ ATKY SVLL VLTD GVVS DMAE TRTA IVRA SRLP MSII IVGV GNAD FSDM RLLD GDDG PLRC PRGV PAAR DIVQ FVPF RDFK DAAP SALA KCVL AEVP RQVV EYYA SQGI SPGA PRPC TLAT TPSP SP |
| Gene ID: | 9362 |
| Uniprot: | O95741 |
| Cellular Location: | Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Endosome, Perikaryon, clathrin-coated vesicle, dendrite |
| Calculated MW: | 61kDa/67kDa |
| Observed MW: | 62kDa |
| Synonyms: | CPNE6, copine-6 |
| Background: | This gene encodes a member of the copine family. Members of this family are calcium-dependent, phospholipid-binding proteins with C2 domains, two calcium- and phospholipid-binding domains. Through their domain structure and lipid binding capabilities, these proteins may play a role in membrane trafficking. This protein is thought to be brain-specific and has a domain structure of two N-terminal C2 domains and one von Willebrand factor A domain. It may have a role in synaptic plasticity. |
| UniProt Protein Function: | CPNE6: May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties. May have a role in synaptic plasticity. Belongs to the copine family. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: membrane; axon; dendrite Molecular Function:phosphatidylserine binding; transporter activity; calcium ion binding Biological Process: vesicle-mediated transport; nervous system development; synaptic transmission; lipid metabolic process |
| NCBI Summary: | This gene encodes a member of the copine family. Members of this family are calcium-dependent, phospholipid-binding proteins with C2 domains, two calcium- and phospholipid-binding domains. Through their domain structure and lipid binding capabilities, these proteins may play a role in membrane trafficking. This protein is thought to be brain-specific and has a domain structure of two N-terminal C2 domains and one von Willebrand factor A domain. It may have a role in synaptic plasticity. [provided by RefSeq, Jul 2013] |
| UniProt Code: | O95741 |
| NCBI GenInfo Identifier: | 67476948 |
| NCBI Gene ID: | 9362 |
| NCBI Accession: | O95741.3 |
| UniProt Secondary Accession: | O95741,Q53HA6, Q8WVG1, B2RAG6, B7Z1M3, D3DS55, F5GXN1 |
| UniProt Related Accession: | O95741 |
| Molecular Weight: | 67,641 Da |
| NCBI Full Name: | Copine-6 |
| NCBI Synonym Full Names: | copine VI (neuronal) |
| NCBI Official Symbol: | CPNE6 |
| NCBI Protein Information: | copine-6; N-copine |
| UniProt Protein Name: | Copine-6 |
| UniProt Synonym Protein Names: | Copine VI; Neuronal-copine; N-copine |
| Protein Family: | Copine |
| UniProt Gene Name: | CPNE6 |
| UniProt Entry Name: | CPNE6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CPNE6 antibody (CAB14385) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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