Developmental Biology
Anti-CPLX2 Antibody (CAB7774)
- SKU:
- CAB7774
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-CPLX2 Antibody |
| Antibody SKU: | CAB7774 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human CPLX2 (NP_006641.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, Mouse eye |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human CPLX2 (NP_006641.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDFV MKQA LGGA TKDM GKML GGEE EKDP DAQK KEEE RQEA LRQQ EEER KAKH ARME AERE KVRQ QIRD KYGL KKKE EKEA EEKA ALEQ PCEG SLTR PKKA IPAG CGDE EEEE EESI LDTV LKYL PGPL QDMF KK |
| Gene ID: | 10814 |
| Uniprot: | Q6PUV4 |
| Cellular Location: | Cytoplasm, cytosol |
| Calculated MW: | 15kDa |
| Observed MW: | 15kDa |
| Synonyms: | CPLX2, 921-L, CPX-2, CPX2, Hfb1 |
| Background: | Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | CPLX2: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis. Belongs to the complexin/synaphin family. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 5q35.2 Cellular Component: mast cell granule; cell soma; dendrite; synapse; cytosol Molecular Function:syntaxin-1 binding; calcium-dependent protein binding Biological Process: regulation of exocytosis; nervous system development; synaptic vesicle exocytosis; positive regulation of synaptic plasticity; mast cell degranulation; cell differentiation; vesicle docking during exocytosis |
| NCBI Summary: | Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6PUV4 |
| NCBI GenInfo Identifier: | 51316998 |
| NCBI Gene ID: | 10814 |
| NCBI Accession: | Q6PUV4.2 |
| UniProt Secondary Accession: | Q6PUV4,O09056, Q13329, Q28184, Q52M15, Q64386, B2RAG2 |
| UniProt Related Accession: | Q6PUV4 |
| Molecular Weight: | 15,394 Da |
| NCBI Full Name: | Complexin-2 |
| NCBI Synonym Full Names: | complexin 2 |
| NCBI Official Symbol: | CPLX2 |
| NCBI Official Synonym Symbols: | CPX2; Hfb1; 921-L; CPX-2 |
| NCBI Protein Information: | complexin-2; CPX II; complexin II; synaphin 1; synaphin-1 |
| UniProt Protein Name: | Complexin-2 |
| UniProt Synonym Protein Names: | Complexin II; CPX II; Synaphin-1 |
| Protein Family: | Complexin |
| UniProt Gene Name: | CPLX2 |
| UniProt Entry Name: | CPLX2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CPLX2 antibody (CAB7774) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
View AllClose
Related Products
Human Complexin-2/CPLX2 Recombinant Protein (RPES4707)
Developmental Biology Recombinant Proteins
system_update_altDatasheetHuman Complexin-2/CPLX2 Recombinant Protein Complexin-2 (CPLX2), a member of the complexin/synaphin family, is a soluble pre-synaptic protein believed to regulate neurot
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
