Immunology Antibodies 3
Anti-COPS7A Antibody (CAB8212)
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- SKU:
- CAB8212
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | COPS7A Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8212 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human COPS7A (NP_057403.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, HepG2, NCI-H460, A-549, Mouse brain, Mouse heart, Mouse kidney, Rat heart, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human COPS7A (NP_057403.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSAE VKVT GQNQ EQFL LLAK SAKG AALA TLIH QVLE APGV YVFG ELLD MPNV RELA ESDF ASTF RLLT VFAY GTYA DYLA EARN LPPL TEAQ KNKL RHLS VVTL AAKV KCIP YAVL LEAL ALRN VRQL EDLV IEAV YADV LRGS LDQR NQRL EVDY SIGR DIQR QDLS AIAR TLQE WCVG CEVV LSGI EEQV SRAN QHKE QQLG LKQQ IESE VANL KKTI KVTT AAAA AATS QDPE QHLT ELRE PAPG TNQR QPSK KASK GKGL RGSA KIWS KSN |
| Gene ID: | 50813 |
| Uniprot: | Q9UBW8 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 30kDa |
| Observed MW: | 30kDa |
| Synonyms: | COPS7A, CSN7, CSN7A, SGN7a |
| Background: | This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. |
| UniProt Protein Function: | COPS7A: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN7/EIF3M family. CSN7 subfamily. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 12p13.31 Cellular Component: cytoplasm; nucleoplasm; signalosome Molecular Function:protein binding Biological Process: cullin deneddylation; nucleotide-excision repair, DNA damage recognition; transcription-coupled nucleotide-excision repair |
| NCBI Summary: | This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014] |
| UniProt Code: | Q9UBW8 |
| NCBI GenInfo Identifier: | 55976618 |
| NCBI Gene ID: | 50813 |
| NCBI Accession: | Q9UBW8.1 |
| UniProt Secondary Accession: | Q9UBW8,Q9NVX3, Q9UJW4, A8K9A6, |
| UniProt Related Accession: | Q9UBW8 |
| Molecular Weight: | 30,277 Da |
| NCBI Full Name: | COP9 signalosome complex subunit 7a |
| NCBI Synonym Full Names: | COP9 signalosome subunit 7A |
| NCBI Official Symbol: | COPS7A |
| NCBI Official Synonym Symbols: | CSN7; CSN7A; SGN7a |
| NCBI Protein Information: | COP9 signalosome complex subunit 7a |
| UniProt Protein Name: | COP9 signalosome complex subunit 7a |
| UniProt Synonym Protein Names: | Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a |
| UniProt Gene Name: | COPS7A |
| UniProt Entry Name: | CSN7A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using COPS7A antibody (CAB8212) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using COPS7A antibody (CAB8212) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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