Cell Biology Antibodies 12
Anti-COPS4 Antibody (CAB8214)
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- SKU:
- CAB8214
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | COPS4 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8214 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human COPS4 (NP_057213.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human COPS4 (NP_057213.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAA VRQD LAQL MNSS GSHK DLAG KYRQ ILEK AIQL SGAE QLEA LKAF VEAM VNEN VSLV ISRQ LLTD FCTH LPNL PDST AKEI YHFT LEKI QPRV ISFE EQVA SIRQ HLAS IYEK EEDW RNAA QVLV GIPL ETGQ KQYN VDYK LETY LKIA RLYL EDDD PVQA EAYI NRAS LLQN ESTN EQLQ IHYK VCYA RVLD YRRK FIEA AQRY NELS YKTI VHES ERLE ALKH ALHC TILA SAGQ QRSR MLAT LFKD ERCQ QLAA YGIL EKMY LDRI IRGN QLQE FAAM LMPH QKAT TADG SSIL DRAV IEHN LL |
| Gene ID: | 51138 |
| Uniprot: | Q9BT78 |
| Cellular Location: | Cytoplasm, Cytoplasmic vesicle, Nucleus, secretory vesicle, synaptic vesicle |
| Calculated MW: | 40kDa/46kDa |
| Observed MW: | Refer to figures |
| Synonyms: | COPS4, CSN4, SGN4 |
| Background: | This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | COPS4: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN4 family. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 4q21.22 Cellular Component: nucleoplasm; signalosome; synaptic vesicle; nucleus; cell junction Molecular Function:protein binding Biological Process: protein deneddylation; cullin deneddylation |
| NCBI Summary: | This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | Q9BT78 |
| NCBI GenInfo Identifier: | 55976582 |
| NCBI Gene ID: | 51138 |
| NCBI Accession: | Q9BT78.1 |
| UniProt Secondary Accession: | Q9BT78,Q561W7, Q9NW31, Q9Y677, B3KN88, B3KST5, |
| UniProt Related Accession: | Q9BT78 |
| Molecular Weight: | 40,197 Da |
| NCBI Full Name: | COP9 signalosome complex subunit 4 |
| NCBI Synonym Full Names: | COP9 signalosome subunit 4 |
| NCBI Official Symbol: | COPS4 |
| NCBI Official Synonym Symbols: | CSN4 |
| NCBI Protein Information: | COP9 signalosome complex subunit 4; COP9 constitutive photomorphogenic homolog subunit 4; JAB1-containing signalosome subunit 4; SGN4 |
| UniProt Protein Name: | COP9 signalosome complex subunit 4 |
| UniProt Synonym Protein Names: | JAB1-containing signalosome subunit 4 |
| UniProt Gene Name: | COPS4 |
| UniProt Entry Name: | CSN4_HUMAN |
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