Name: Anti-CNTNAP2 Antibody (CAB7466)
Brand: Cell Biology Antibodies 11
SKU: CAB7466
Availability: OutOfStock

Antibody Name:	Anti-CNTNAP2 Antibody
Antibody SKU:	CAB7466
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 180-400 of human CNTNAP2 (NP_054860.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse
Positive Samples:	Mouse brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 180-400 of human CNTNAP2 (NP_054860.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	GCSY WADV INFD GHVV LPYR FRNK KMKT LKDV IALN FKTS ESEG VILH GEGQ QGDY ITLE LKKA KLVL SLNL GSNQ LGPI YGHT SVMT GSLL DDHH WHSV VIER QGRS INLT LDRS MQHF RTNG EFDY LDLD YEIT FGGI PFSG KPSS SSRK NFKG CMES INYN GVNI TDLA RRKK LEPS NVGN LSFS CVEP YTVP VFFN ATSY LEVP GRLN QDLF SVSF Q
Gene ID:	26047
Uniprot:	Q9UHC6
Cellular Location:	Cell projection, Membrane, Single-pass type I membrane protein, axon
Calculated MW:	11kDa/148kDa
Observed MW:	160kDa

Synonyms:

CNTNAP2, AUTS15, CASPR2, CDFE, NRXN4, PTHSL1

Background:

This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.

UniProt Protein Function:	CNTNAP2: May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction. Associates with KCNA2. Predominantly expressed in nervous system. Belongs to the neurexin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Motility/polarity/chemotaxis; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q35 Cellular Component: axolemma; cell surface; early endosome; Golgi apparatus; membrane; voltage-gated potassium channel complex Molecular Function:enzyme binding; protein binding Biological Process: adult behavior; brain development; cerebral cortex development; clustering of voltage-gated potassium channels; learning; limbic system development; neurite development; social behavior; striatum development; thalamus development; vocal learning Disease: Autism, Susceptibility To, 15; Cortical Dysplasia-focal Epilepsy Syndrome
NCBI Summary:	This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.[provided by RefSeq, Mar 2010]
UniProt Code:	Q9UHC6
NCBI GenInfo Identifier:	17433089
NCBI Gene ID:	26047
NCBI Accession:	Q9UHC6.1
UniProt Secondary Accession:	Q9UHC6,Q14DG2, Q52LV1, Q5H9Q7, Q9UQ12, D3DWG2,
UniProt Related Accession:	Q9UHC6
Molecular Weight:	11,899 Da
NCBI Full Name:	Contactin-associated protein-like 2
NCBI Synonym Full Names:	contactin associated protein-like 2
NCBI Official Symbol:	CNTNAP2
NCBI Official Synonym Symbols:	CDFE; NRXN4; AUTS15; CASPR2; PTHSL1
NCBI Protein Information:	contactin-associated protein-like 2
UniProt Protein Name:	Contactin-associated protein-like 2
UniProt Synonym Protein Names:	Cell recognition molecule Caspr2
Protein Family:	Contactin-associated protein
UniProt Gene Name:	CNTNAP2
UniProt Entry Name:	CNTP2_HUMAN

Western blot analysis of extracts of mouse brain, using CNTNAP2 antibody (CAB7466) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

ELISA Kits

Human CNTNAP2 / Contactin Associated Protein Like Protein 2 ELISA Kit

Human CNTNAP2 (Contactin Associated Protein Like Protein 2) CLIA Kit (HUES00247)

Human CNTNAP2 (Contactin Associated Protein Like Protein 2) ELISA Kit (HUES01566)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)