KO Validated Antibodies 1

Anti-CNP Antibody (CAB18009)[KO Validated]

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SKU:
CAB18009
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CNP Antibody [KO Validated]
Antibody SKU:CAB18009
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 152-421 of human CNP (NP_149124.3).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 152-421 of human CNP (NP_149124.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TAWR LDCA QLKE KNQW QLSA DDLK KLKP GLEK DFLP LYFG WFLT KKSS ETLR KAGQ VFLE ELGN HKAF KKEL RQFV PGDE PREK MDLV TYFG KRPP GVLH CTTK FCDY GKAP GAEE YAQQ DVLK KSYS KAFT LTIS ALFV TPKT TGAR VELS EQQL QLWP SDVD KLSP TDNL PRGS RAHI TLGC AADV EAVQ TGLD LLEI LRQE KGGS RGEE VGEL SRGK LYSL GNGR WMLT LAKN MEVR AIFT GYYG KGKP VPTQ GSRK GGAL QSCT II
Gene ID:1267
Uniprot:P09543
Cellular Location:Lipid-anchor, Melanosome, Membrane
Calculated MW:45kDa/47kDa
Observed MW:47kDa
Anti-CNP Antibody [KO Validated] (CAB18009)Western blot analysis of extracts from normal (control) and CNP knockout (KO) HeLa cells, using CNP antibody (CAB18009) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Synonyms:CNP, CNP1, CNPase
Background:
UniProt Protein Function:CNP: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Exists as monomers and homodimers. Belongs to the cyclic nucleotide phosphodiesterase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Phosphodiesterase; EC 3.1.4.37; Cell development/differentiation

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: nucleoplasm; microtubule; extracellular space; mitochondrial outer membrane; microvillus; membrane; perinuclear region of cytoplasm; mitochondrial inner membrane; cytoplasm; melanosome; plasma membrane; pseudopodium; nucleus

Molecular Function:cyclic nucleotide binding; RNA binding; 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity

Biological Process: synaptic transmission; substantia nigra development; axonogenesis; adult locomotory behavior; response to toxin; forebrain development; oligodendrocyte differentiation; response to lipopolysaccharide; microtubule cytoskeleton organization and biogenesis; regulation of mitochondrial membrane permeability; cyclic nucleotide catabolic process; aging

UniProt Code:P09543
NCBI GenInfo Identifier:1705945
NCBI Gene ID:1267
NCBI Accession:P09543.2
UniProt Related Accession:P09543
Molecular Weight:421
NCBI Full Name:2',3'-cyclic-nucleotide 3'-phosphodiesterase
NCBI Synonym Full Names:2',3'-cyclic nucleotide 3' phosphodiesterase
NCBI Official Symbol:CNP  
NCBI Official Synonym Symbols:CNP1  
NCBI Protein Information:2',3'-cyclic-nucleotide 3'-phosphodiesterase; CNPase; 2', 3' cyclic nucleotide 3' phosphohydrolase
UniProt Protein Name:2',3'-cyclic-nucleotide 3'-phosphodiesterase
Protein Family:2',3'-cyclic-nucleotide 3'-phosphodiesterase
UniProt Gene Name:CNP  
UniProt Entry Name:CN37_HUMAN
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