Signal Transduction Antibodies 1

Anti-CNGA4 Antibody (CAB14720)

(No reviews yet) Write a Review
SKU:
CAB14720
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-CNGA4 Antibody
Antibody SKU:CAB14720
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 416-575 of human CNGA4 (NP_001032406.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:NCI-H460, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 416-575 of human CNGA4 (NP_001032406.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ISII NIKG NMSG NRRT ANIK SLGY SDLF CLSK EDLR EVLS EYPQ AQTI MEEK GREI LLKM NKLD VNAE AAEI ALQE ATES RLRG LDQQ LDDL QTKF ARLL AELE SSAL KIAY RIER LEWQ TREW PMPE DLAE ADDE GEPE EGTS KDEE GRAS QEGP PGPE
Gene ID:1262
Uniprot:Q8IV77
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:47kDa/65kDa
Observed MW:66kDa
Synonyms:CNGA4, CNCA2, CNG-4, CNG4, CNG5, CNGB2, OCNC2, OCNCBETA, OCNCb
Background:
UniProt Protein Function:CNGA4: Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: Golgi membrane; integral to plasma membrane

Molecular Function:cGMP binding; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; voltage-gated potassium channel activity

Biological Process: regulation of membrane potential

NCBI Summary:CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]
UniProt Code:Q8IV77
NCBI GenInfo Identifier:311033466
NCBI Gene ID:1262
NCBI Accession:Q8IV77.3
UniProt Related Accession:Q8IV77
Molecular Weight:47,743 Da
NCBI Full Name:Cyclic nucleotide-gated cation channel alpha-4
NCBI Synonym Full Names:cyclic nucleotide gated channel alpha 4
NCBI Official Symbol:CNGA4  
NCBI Official Synonym Symbols:CNG4; CNG5; CNCA2; CNG-4; CNGB2; OCNC2; OCNCb; OCNCBETA  
NCBI Protein Information:cyclic nucleotide-gated cation channel alpha-4
UniProt Protein Name:Cyclic nucleotide-gated cation channel alpha-4
UniProt Synonym Protein Names:Cyclic nucleotide-gated channel alpha-4; CNG channel alpha-4; CNG-4; CNG4
Protein Family:Cyclic nucleotide-gated cation channel
UniProt Gene Name:CNGA4  
UniProt Entry Name:CNGA4_HUMAN
Anti-CNGA4 Antibody (CAB14720)Western blot analysis of extracts of various cell lines, using CNGA4 antibody (CAB14720) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
View AllClose

0 Reviews

View AllClose

Related Products