Cell Biology Antibodies 4

Anti-CLK1 Antibody (CAB13653)

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SKU:
CAB13653
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CLK1 Antibody
Antibody SKU:CAB13653
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human CLK1 (NP_004062.2).
Application:IF
Recommended Dilution:IF 1:50 - 1:100
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human CLK1 (NP_004062.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MRHS KRTY CPDW DDKD WDYG KWRS SSSH KRRK RSHS SAQE NKRC KYNH SKMC DSHY LESR SINE KDYH SRRY IDEY RNDY TQGC EPGH RQRD HESR YQNH SSKS SGRS GRSS YKSK HRIH HSTS HRRS HG
Gene ID:1195
Uniprot:P49759
Cellular Location:Nucleus
Calculated MW:16kDa/57kDa/61kDa
Observed MW:
Synonyms:CLK1, CLK, CLK/STY, STY
Background:This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:CLK1: a CMGC kinase of the CLK family. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May play a role in regulating RNA splicing.
UniProt Protein Details:

Protein type:Protein kinase, dual-specificity (non-receptor); Protein kinase, CMGC; EC 2.7.12.1; Kinase, protein; CMGC group; CLK family

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: cytoplasm; nucleus

Molecular Function:protein serine/threonine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding

Biological Process: cell proliferation; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; regulation of RNA splicing; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation

NCBI Summary:This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
UniProt Code:P49759
NCBI GenInfo Identifier:206729857
NCBI Gene ID:1195
NCBI Accession:P49759.2
UniProt Secondary Accession:P49759,Q0P694, Q8N5V8, B4DFW7,
UniProt Related Accession:P49759
Molecular Weight:484
NCBI Full Name:Dual specificity protein kinase CLK1
NCBI Synonym Full Names:CDC-like kinase 1
NCBI Official Symbol:CLK1  
NCBI Official Synonym Symbols:CLK; STY; CLK/STY  
NCBI Protein Information:dual specificity protein kinase CLK1; CDC28/CDC2-like kinase; protein tyrosine kinase STY
UniProt Protein Name:Dual specificity protein kinase CLK1
UniProt Synonym Protein Names:CDC-like kinase 1
Protein Family:Dual specificity protein kinase
UniProt Gene Name:CLK1  
UniProt Entry Name:CLK1_HUMAN
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