Immunology Antibodies 2

Anti-CLEC4A Antibody (CAB2713)

(No reviews yet) Write a Review
SKU:
CAB2713
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-CLEC4A Antibody
Antibody SKU:CAB2713
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 70-237 of human CLEC4A (NP_057268.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:A-549, HeLa, HT-29, Mouse spleen, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 70-237 of human CLEC4A (NP_057268.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QKYS QLLE KKTT KELV HTTL ECVK KNMP VEET AWSC CPKN WKSF SSNC YFIS TESA SWQD SEKD CARM EAHL LVIN TQEE QDFI FQNL QEES AYFV GLSD PEGQ RHWQ WVDQ TPYN ESST FWHP REPS DPNE RCVV LNFR KSPK RWGW NDVN CLGP QRSV CEMM KIHL
Gene ID:50856
Uniprot:Q9UMR7
Cellular Location:Membrane, Single-pass type II membrane protein
Calculated MW:19kDa/23kDa/27kDa
Observed MW:25kDa
Synonyms:CLEC4A, CD367, CLECSF6, DCIR, DDB27, HDCGC13P, LLIR
Background:This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
UniProt Protein Function:CLEC4A: May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: integral to plasma membrane

Molecular Function:transmembrane receptor activity; carbohydrate binding

Biological Process: cell surface receptor linked signal transduction; innate immune response; cell adhesion

NCBI Summary:This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UMR7
NCBI GenInfo Identifier:59797977
NCBI Gene ID:50856
NCBI Accession:Q9UMR7.1
UniProt Secondary Accession:Q9UMR7,Q17R69, Q8WXW9, Q9H2Z9, Q9NS33, Q9UI34,
UniProt Related Accession:Q9UMR7
Molecular Weight:237
NCBI Full Name:C-type lectin domain family 4 member A
NCBI Synonym Full Names:C-type lectin domain family 4, member A
NCBI Official Symbol:CLEC4A  
NCBI Official Synonym Symbols:DCIR; LLIR; DDB27; CLECSF6; HDCGC13P  
NCBI Protein Information:C-type lectin domain family 4 member A; C-type lectin DDB27; lectin-like immunoreceptor; dendritic cell immunoreceptor; C-type lectin superfamily member 6; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6
UniProt Protein Name:C-type lectin domain family 4 member A
UniProt Synonym Protein Names:C-type lectin DDB27; C-type lectin superfamily member 6; Dendritic cell immunoreceptor; Lectin-like immunoreceptor
UniProt Gene Name:CLEC4A  
UniProt Entry Name:CLC4A_HUMAN
Anti-CLEC4A Antibody (CAB2713)Western blot analysis of extracts of various cell lines, using CLEC4A antibody (CAB2713) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s.
View AllClose

0 Reviews

View AllClose

Related Products

Human CLEC4A/DCIR Recombinant Protein (RPES1477)

Human CLEC4A/DCIR Recombinant Protein (RPES1477)

system_update_altDatasheetHuman CLEC4A/DCIR Recombinant Protein Dendritic cell immunoreceptor (DCIR), also known as C-type lectin domain family 4 member A (CLEC4A), C-type lectin superfamily memb