Cell Biology Antibodies 3
Anti-CLDN11 Antibody (CAB12478)
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- SKU:
- CAB12478
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CLDN11 Antibody |
| Antibody SKU: | CAB12478 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN11 (NP_005593.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NCI-H460, DU145, SW480, Mouse kidney, Mouse lung, Rat brain, Rat kidney, Rat lung |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN11 (NP_005593.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVAT CLQV VGFV TSFV GWIG VIVT TSTN DWVV TCGY TIPT CRKL DELG SKGL WADC VMAT GLYH CKPL VDIL ILPG YVQA CRAL MIAA SVLG LPAI LLLL |
| Gene ID: | 5010 |
| Uniprot: | O75508 |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, tight junction |
| Calculated MW: | 21kDa |
| Observed MW: | 23kDa |
| Synonyms: | CLDN11, OSP, OTM |
| Background: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | Claudin-11: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Belongs to the claudin family. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 3q26.2 Cellular Component: plasma membrane; tight junction Molecular Function:identical protein binding; protein binding Biological Process: calcium-independent cell-cell adhesion |
| NCBI Summary: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010] |
| UniProt Code: | O75508 |
| NCBI GenInfo Identifier: | 6685300 |
| NCBI Gene ID: | 5010 |
| NCBI Accession: | O75508.2 |
| UniProt Secondary Accession: | O75508,Q5U0P3, B2R7C1, D3DNQ5, |
| UniProt Related Accession: | O75508 |
| Molecular Weight: | 22kDa |
| NCBI Full Name: | Claudin-11 |
| NCBI Synonym Full Names: | claudin 11 |
| NCBI Official Symbol: | CLDN11 |
| NCBI Official Synonym Symbols: | OSP; OTM |
| NCBI Protein Information: | claudin-11 |
| UniProt Protein Name: | Claudin-11 |
| UniProt Synonym Protein Names: | Oligodendrocyte-specific protein |
| Protein Family: | Claudin |
| UniProt Gene Name: | CLDN11 |
 | Western blot analysis of extracts of various cell lines, using CLDN11 antibody (CAB12478) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
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