Epigenetics & Nuclear Signaling Antibodies 1
Anti-CIR1 Antibody (CAB10133)
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- SKU:
- CAB10133
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-CIR1 Antibody |
| Antibody SKU: | CAB10133 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human CIR1 (NP_004873.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U2OS |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human CIR1 (NP_004873.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGKS FANF MCKK DFHP ASKS NIKK VWMA EQKI SYDK KKQE ELMQ QYLK EQES YDNR LLMG DERV KNGL NFMY EAPP GAKK ENKE KEET EGET EYKF EWQK GAPR EKYA KDDM NIRD QPFG IQVR NVRC IKCH KWGH VNTD RECP LFGL SGIN ASSV PTDG |
| Gene ID: | 9541 |
| Uniprot: | Q86X95 |
| Cellular Location: | Cytoplasm, Nucleus speckle, centrosome, cytoskeleton, microtubule organizing center |
| Calculated MW: | 23kDa/52kDa |
| Observed MW: | 52kDa |
| Synonyms: | CIR1, CIR |
| Background: |
| UniProt Protein Function: | CIR: May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 2q31.1 Cellular Component: histone deacetylase complex; nucleus Molecular Function:protein binding; RNA polymerase II transcription factor activity, enhancer binding; transcription corepressor activity; transcription factor activity Biological Process: negative regulation of transcription, DNA-dependent |
| UniProt Code: | Q86X95 |
| NCBI GenInfo Identifier: | 74727790 |
| NCBI Gene ID: | 9541 |
| NCBI Accession: | Q86X95.1 |
| UniProt Secondary Accession: | Q86X95,O95367, Q12804, Q4G1B9, Q6PJI4, Q8IWI2, A6NFI6 A8K8M4, |
| UniProt Related Accession: | Q86X95 |
| Molecular Weight: | 23,274 Da |
| NCBI Full Name: | Corepressor interacting with RBPJ 1 |
| NCBI Synonym Full Names: | corepressor interacting with RBPJ, 1 |
| NCBI Official Symbol: | CIR1 |
| NCBI Official Synonym Symbols: | CIR |
| NCBI Protein Information: | corepressor interacting with RBPJ 1 |
| UniProt Protein Name: | Corepressor interacting with RBPJ 1 |
| UniProt Synonym Protein Names: | CBF1-interacting corepressor; Recepin |
| Protein Family: | Circulin |
| UniProt Gene Name: | CIR1 |
| UniProt Entry Name: | CIR1_HUMAN |
 | Western blot analysis of extracts of U2OS cells, using CIR1 antibody (CAB10133) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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