Epigenetics & Nuclear Signaling Antibodies 4

Anti-CIAO1 Antibody (CAB7355)

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SKU:
CAB7355
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-CIAO1 Antibody
Antibody SKU:CAB7355
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human CIAO1 (NP_004795.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, Mouse kidney, Mouse thymus, Mouse heart, Rat heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human CIAO1 (NP_004795.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MKDS LVLL GRVP AHPD SRCW FLAW NPAG TLLA SCGG DRRI RIWG TEGD SWIC KSVL SEGH QRTV RKVA WSPC GNYL ASAS FDAT TCIW KKNQ DDFE CVTT LEGH ENEV KSVA WAPS GNLL ATCS RDKS VWVW EVDE EDEY ECVS VLNS HTQD VKHV VWHP SQEL LASA SYDD TVKL YREE EDDW VCCA TLEG HEST VWSL AFDP SGQR LASC SDDR TVRI WRQY LPGN EQGV ACSG SDPS WKCI CTLS GFHS RTIY DIAW CQLT GALA TACG DDAI RVFQ EDPN SDPQ QPTF SLTA HLHQ AHSQ DVNC VAWN PKEP GLLA SCSD DGEV AFWK YQRP EGL
Gene ID:9391
Uniprot:O76071
Cellular Location:
Calculated MW:37kDa
Observed MW:38kDa
Synonyms:CIAO1, CIA1, WDR39
Background:
UniProt Protein Function:CIAO1: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. Belongs to the WD repeat CIA1 family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 2q11.2

Biological Process: regulation of transcription from RNA polymerase II promoter; iron-sulfur cluster assembly; positive regulation of cell proliferation; chromosome segregation

UniProt Code:O76071
NCBI GenInfo Identifier:12229745
NCBI Gene ID:9391
NCBI Accession:O76071.1
UniProt Secondary Accession:O76071,Q53FM5, A0MNN9,
UniProt Related Accession:O76071
Molecular Weight:339
NCBI Full Name:Probable cytosolic iron-sulfur protein assembly protein CIAO1
NCBI Synonym Full Names:cytosolic iron-sulfur assembly component 1
NCBI Official Symbol:CIAO1  
NCBI Official Synonym Symbols:CIA1; WDR39  
NCBI Protein Information:probable cytosolic iron-sulfur protein assembly protein CIAO1; WD40 protein Ciao1; WD repeat domain 39; WD repeat-containing protein 39; cytosolic iron-sulfur protein assembly 1 homolog
UniProt Protein Name:Probable cytosolic iron-sulfur protein assembly protein CIAO1
UniProt Synonym Protein Names:WD repeat-containing protein 39
Protein Family:Probable cytosolic iron-sulfur protein assembly protein
UniProt Gene Name:CIAO1  
UniProt Entry Name:CIAO1_HUMAN
Anti-CIAO1 Antibody (CAB7355)Western blot analysis of extracts of various cell lines, using CIAO1 antibody (CAB7355) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
Anti-CIAO1 Antibody (CAB7355)Immunohistochemistry of paraffin-embedded rat brain using CIAO1 antibody (CAB7355) at dilution of 1:100 (40x lens).
Anti-CIAO1 Antibody (CAB7355)Immunohistochemistry of paraffin-embedded human kidney using CIAO1 antibody (CAB7355) at dilution of 1:100 (40x lens).
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