Cell Biology Antibodies 16

Anti-CHTF18 Antibody (CAB17752)

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SKU:
CAB17752
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CHTF18 Antibody
Antibody SKU:CAB17752
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 794-975 of human CHTF18 (NP_071375.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 794-975 of human CHTF18 (NP_071375.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GTML AYSL TYRQ ERTP DGQY IYRL EPNV EELC RFPE LPAR KPLT YQTK QLIA REIE VEKM RRAE ASAR VENS PQVD GSPP GLEG LLGG IGEK GVHR PAPR NHEQ RLEH IMRR AARE EQPE KDFF GRVV VRST AVPS AGDT APEQ DSVE RRMG TAVG RSEV WFRF NEGV SNAV RRSL YIRD LL
Gene ID:63922
Uniprot:Q8WVB6
Cellular Location:
Calculated MW:
Observed MW:130kDa
Anti-CHTF18 Antibody (CAB17752)Western blot - CHTF18 Polyclonal Antibody (CAB17752)
Synonyms:C16orf41, C321D2.2, C321D2.3, C321D2.4, CHL12, Ctf18, RUVBL, CHTF18
Background:This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition. [provided by RefSeq, Jan 2016]
UniProt Protein Function:CTF18: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18- RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH. Belongs to the activator 1 small subunits family. CTF18 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA replication

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cytoplasm; membrane; nucleoplasm

Molecular Function:DNA clamp loader activity; protein binding; single-stranded DNA-dependent ATPase activity

NCBI Summary:This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition. [provided by RefSeq, Jan 2016]
UniProt Code:Q8WVB6
NCBI GenInfo Identifier:74751544
NCBI Gene ID:63922
NCBI Accession:Q8WVB6.1
UniProt Secondary Accession:Q8WVB6,Q7Z6Y4, Q7Z6Y6, Q9BR83, Q9BRG5, Q9H7K3, B7ZBA2 D3DU68,
UniProt Related Accession:Q8WVB6
Molecular Weight:61,869 Da
NCBI Full Name:Chromosome transmission fidelity protein 18 homolog
NCBI Synonym Full Names:chromosome transmission fidelity factor 18
NCBI Official Symbol:CHTF18  
NCBI Official Synonym Symbols:CHL12; Ctf18; RUVBL; C16orf41; C321D2.2; C321D2.3; C321D2.4  
NCBI Protein Information:chromosome transmission fidelity protein 18 homolog
UniProt Protein Name:Chromosome transmission fidelity protein 18 homolog
UniProt Synonym Protein Names:CHL12
Protein Family:Chromosome transmission fidelity protein
UniProt Gene Name:CHTF18  
UniProt Entry Name:CTF18_HUMAN
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