Cell Biology Antibodies 12

Anti-CHL1 Antibody (CAB9681)

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SKU:
CAB9681
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CHL1 Antibody
Antibody SKU:CAB9681
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 690-950 of human CHL1 (NP_001240316.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-251MG, NCI-H460, Jurkat, Mouse brain, Rat spinal cord, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 690-950 of human CHL1 (NP_001240316.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NEVG RSQP SQPS DHHE TPPA APDR NPQN IRVQ ASQP KEMI IKWE PLKS MEQN GPGL EYRV TWKP QGAP VEWE EETV TNHT LRVM TPAV YAPY DVKV QAIN QLGS GPDP QSVT LYSG EDYP DTAP VIHG VDVI NSTL VKVT WSTV PKDR VHGR LKGY QINW WKTK SLLD GRTH PKEV NILR FSGQ RNSG MVPS LDAF SEFH LTVL AYNS KGAG PESE PYIF QTPE GVPE QPTF LKVI KVDK DTAT LSWG LPKK LNGN LTGY L
Gene ID:10752
Uniprot:O00533
Cellular Location:Cell membrane, Secreted, Single-pass type I membrane protein, extracellular matrix, extracellular space
Calculated MW:135kDa/136kDa
Observed MW:135kDa
Synonyms:CHL1, CALL, L1CAM2
Background:The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants.
UniProt Protein Function:CHL1: Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane. Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell adhesion; Cell development/differentiation; Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p26.3

Cellular Component: apical part of cell; dendrite; integral component of membrane; plasma membrane; proteinaceous extracellular matrix

Molecular Function:protease binding

Biological Process: adult locomotory behavior; axon guidance; axon regeneration; cell adhesion; cognition; negative regulation of neuron apoptosis; neuron migration; signal transduction

NCBI Summary:The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Nov 2011]
UniProt Code:O00533
NCBI GenInfo Identifier:358438179
NCBI Gene ID:10752
NCBI Accession:NP_001240316.1
UniProt Secondary Accession:O00533,Q2M3G2, Q59FY0, B7ZL03,
UniProt Related Accession:O00533
Molecular Weight:
NCBI Full Name:neural cell adhesion molecule L1-like protein isoform 2
NCBI Synonym Full Names:cell adhesion molecule L1 like
NCBI Official Symbol:CHL1  
NCBI Official Synonym Symbols:CALL; L1CAM2  
NCBI Protein Information:neural cell adhesion molecule L1-like protein
UniProt Protein Name:Neural cell adhesion molecule L1-like protein
UniProt Synonym Protein Names:Close homolog of L1
Protein Family:ATP-dependent DNA helicase
UniProt Gene Name:CHL1  
Anti-CHL1 Polyclonal Antibody (CAB9681)Western blot analysis of extracts of various cell lines, using CHL1 antibody (CAB9681) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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