Developmental Biology

Anti-CHD5 Antibody (CAB8578)

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SKU:
CAB8578
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-CHD5 Antibody
Antibody SKU:CAB8578
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1530-1700 of human CHD5 (NP_056372.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:MCF7
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1530-1700 of human CHD5 (NP_056372.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IPEG PEGK KSGE VISS DPNT PVPA SPAH LLPA PLGL PDKM EAQL GYMD EKDP GAQK PRQP LEVQ ALPA ALDR VESE DKHE SPAS KERA REER PEET EKAP PSPE QLPR EEVL PEKE KILD KLEL SLIH SRGD SSEL RPDD TKAE EKEP IETQ QNGD KEED DEGK KEDK KGK
Gene ID:26038
Uniprot:Q8TDI0
Cellular Location:Nucleus
Calculated MW:223kDa
Observed MW:223kDa
Synonyms:CHD5, CHD-5
Background:This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma.
UniProt Protein Function:CHD-5: May play a role in the development of the nervous system and the pathogenesis of neural tumors. Belongs to the SNF2/RAD54 helicase family.
UniProt Protein Details:

Protein type:EC 3.6.4.12; DNA-binding; Tumor suppressor; Helicase

Chromosomal Location of Human Ortholog: 1p36.31

Cellular Component: heterochromatin; membrane; nucleus; NuRD complex

Biological Process: cerebral cortex neuron differentiation; negative regulation of cell proliferation; spermatogenesis, exchange of chromosomal proteins

NCBI Summary:This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. [provided by RefSeq, Feb 2012]
UniProt Code:Q8TDI0
NCBI GenInfo Identifier:51701343
NCBI Gene ID:26038
NCBI Accession:Q8TDI0.1
UniProt Secondary Accession:Q8TDI0,O75032, Q5TG89, Q7LGH2, Q9UFR9,
UniProt Related Accession:Q8TDI0
Molecular Weight:223,050 Da
NCBI Full Name:Chromodomain-helicase-DNA-binding protein 5
NCBI Synonym Full Names:chromodomain helicase DNA binding protein 5
NCBI Official Symbol:CHD5  
NCBI Official Synonym Symbols:CHD-5  
NCBI Protein Information:chromodomain-helicase-DNA-binding protein 5
UniProt Protein Name:Chromodomain-helicase-DNA-binding protein 5
UniProt Synonym Protein Names:ATP-dependent helicase CHD5
Protein Family:Chromodomain-helicase-DNA-binding protein
UniProt Gene Name:CHD5  
UniProt Entry Name:CHD5_HUMAN
Anti-CHD5 Polyclonal Antibody (CAB8578)Western blot analysis of extracts of MCF-7 cells, using CHD5 antibody (CAB8578) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.
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