Cardiovascular Antibodies

Anti-CHD2 Antibody (CAB13476)

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SKU:
CAB13476
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular

Description

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Antibody Name:Anti-CHD2 Antibody
Antibody SKU:CAB13476
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 242-501 of human CHD2 (NP_001036037.1).
Application:IF
Recommended Dilution:IF 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 242-501 of human CHD2 (NP_001036037.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SDDL IEMT GEGV DEQQ DNSE TIEK VLDS RLGK KGAT GAST TVYA IEAN GDPS GDFD TEKD EGEI QYLI KWKG WSYI HSTW ESEE SLQQ QKVK GLKK LENF KKKE DEIK QWLG KVSP EDVE YFNC QQEL ASEL NKQY QIVE RVIA VKTS KSTL GQTD FPAH SRKP APSN EPEY LCKW MGLP YSEC SWED EALI GKKF QNCI DSFH SRNN SKTI PTRE CKAL KQRP RFVA LKKQ PAYL GGEN LELR DYQL EGLN WLAH SWCK
Gene ID:1106
Uniprot:O14647
Cellular Location:Nucleus
Calculated MW:56kDa/200kDa/211kDa
Observed MW:
Synonyms:CHD2, EEOC
Background:The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
UniProt Protein Function:CHD-2: Sequence-selective DNA-binding protein. Belongs to the SNF2/RAD54 helicase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.6.4.12; Helicase; DNA-binding

Chromosomal Location of Human Ortholog: 15q26

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; nucleolus; nucleus

Molecular Function:ATP-dependent DNA helicase activity; DNA binding; histone binding; ATP binding

Biological Process: regulation of transcription from RNA polymerase II promoter; muscle development; transcription, DNA-dependent; chromatin modification; response to DNA damage stimulus; DNA duplex unwinding

Disease: Epileptic Encephalopathy, Childhood-onset

NCBI Summary:The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:O14647
NCBI GenInfo Identifier:119370320
NCBI Gene ID:1106
NCBI Accession:O14647.2
UniProt Secondary Accession:O14647,Q96IP5, C6G482,
UniProt Related Accession:O14647
Molecular Weight:1828
NCBI Full Name:Chromodomain-helicase-DNA-binding protein 2
NCBI Synonym Full Names:chromodomain helicase DNA binding protein 2
NCBI Official Symbol:CHD2  
NCBI Official Synonym Symbols:EEOC  
NCBI Protein Information:chromodomain-helicase-DNA-binding protein 2; CHD-2; ATP-dependent helicase CHD2
UniProt Protein Name:Chromodomain-helicase-DNA-binding protein 2
UniProt Synonym Protein Names:ATP-dependent helicase CHD2
Protein Family:Chromodomain-helicase-DNA-binding protein
UniProt Gene Name:CHD2  
UniProt Entry Name:CHD2_HUMAN
Anti-CHD2 Antibody (CAB13476)Immunofluorescence analysis of HeLa cells using CHD2 antibody (CAB13476). Blue: DAPI for nuclear staining.
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