Anti-CHD1L Antibody (CAB17558)
- SKU:
- CAB17558
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ALC1
- Synonyms:
- CHDL
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | CHD1L Rabbit mAb |
| Product Code: | CAB17558 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ALC1, CHDL |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CHD1L |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HepG2 |
| Immunogen: | A synthesized peptide derived from human CHD1L |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9557 |
| Uniprot: | Q86WJ1 |
| Calculated MW: | 101kDa |
| Observed MW: | 101KDa |
| UniProt Protein Function: | CHD1L: DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding. Belongs to the SNF2/RAD54 helicase family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.6.4.12; Helicase; DNA-binding Chromosomal Location of Human Ortholog: 1q12 Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane Molecular Function:ATP-dependent DNA helicase activity; ATPase activity; nucleotide binding; protein binding Biological Process: chromatin remodeling; DNA repair; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 3'-to lesion; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, preincision complex stabilization; response to DNA damage stimulus |
| NCBI Summary: | This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants have been described for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | Q86WJ1 |
| NCBI GenInfo Identifier: | 311033359 |
| NCBI Gene ID: | 9557 |
| NCBI Accession: | Q86WJ1.2 |
| UniProt Secondary Accession: | Q86WJ1,Q53EZ3, Q5VXX7, Q6DD94, Q6PK83, Q86XH3, Q96HF7 Q96SP3, Q9BVJ1, A5YM64, B4DDE1, B5MDZ7, |
| UniProt Related Accession: | Q86WJ1 |
| Molecular Weight: | 69,139 Da |
| NCBI Full Name: | Chromodomain-helicase-DNA-binding protein 1-like |
| NCBI Synonym Full Names: | chromodomain helicase DNA binding protein 1 like |
| NCBI Official Symbol: | CHD1L |
| NCBI Official Synonym Symbols: | ALC1; CHDL |
| NCBI Protein Information: | chromodomain-helicase-DNA-binding protein 1-like |
| UniProt Protein Name: | Chromodomain-helicase-DNA-binding protein 1-like |
| UniProt Synonym Protein Names: | Amplified in liver cancer protein 1 |
| Protein Family: | Chromodomain-helicase-DNA-binding protein |
| UniProt Gene Name: | CHD1L |
| UniProt Entry Name: | CHD1L_HUMAN |
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