Cell Death Antibodies 1
Anti-CHAC1 Antibody (CAB15584)
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- SKU:
- CAB15584
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-CHAC1 Antibody |
| Antibody SKU: | CAB15584 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 45-264 of human CHAC1 (NP_077016.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 45-264 of human CHAC1 (NP_077016.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QESA APNT PPTS QSPT PSAQ FPRN DGDP QALW IFGY GSLV WRPD FAYS DSRV GFVR GYSR RFWQ GDTF HRGS DKMP GRVV TLLE DHEG CTWG VAYQ VQGE QVSK ALKY LNVR EAVL GGYD TKEV TFYP QDAP DQPL KALA YVAT PQNP GYLG PAPE EAIA TQIL ACRG FSGH NLEY LLRL ADFM QLCG PQAQ DEHL AAIV DAVG TMLP CFCP TEQA LALV |
| Gene ID: | 79094 |
| Uniprot: | Q9BUX1 |
| Cellular Location: | Cytoplasm, Golgi apparatus, cytosol, trans-Golgi network |
| Calculated MW: | 23kDa/28kDa |
| Observed MW: | Refer to figures |
| Synonyms: | CHAC1 |
| Background: |
| UniProt Protein Function: | CHAC1: Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. May also act as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Belongs to the chaC family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 15q15.1 Cellular Component: trans-Golgi network; cytosol Molecular Function:protein binding; transferase activity, transferring acyl groups; Notch binding Biological Process: Notch signaling pathway; neurogenesis; metabolic process; negative regulation of Notch signaling pathway; response to unfolded protein |
| UniProt Code: | Q9BUX1 |
| NCBI GenInfo Identifier: | 218563698 |
| NCBI Gene ID: | 79094 |
| NCBI Accession: | NP_077016.2 |
| UniProt Secondary Accession: | Q9BUX1,Q0VIA0, |
| UniProt Related Accession: | Q9BUX1 |
| Molecular Weight: | 23,795 Da |
| NCBI Full Name: | cation transport regulator-like protein 1 isoform a |
| NCBI Synonym Full Names: | ChaC, cation transport regulator homolog 1 (E. coli) |
| NCBI Official Symbol: | CHAC1 |
| NCBI Protein Information: | cation transport regulator-like protein 1; botch; blocks Notch protein; ChaC, cation transport regulator-like 1; gamma-GCT acting on glutathione homolog 1 |
| UniProt Protein Name: | Cation transport regulator-like protein 1 |
| UniProt Synonym Protein Names: | Blocks Notch protein; Botch |
| Protein Family: | Glutathione-specific gamma-glutamylcyclotransferase |
| UniProt Gene Name: | CHAC1 |
| UniProt Entry Name: | CHAC1_HUMAN |
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