Cell Biology Antibodies 1
Anti-CFHR5 Antibody (CAB10367)
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- SKU:
- CAB10367
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CFHR5 Antibody |
| Antibody SKU: | CAB10367 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-569 of human CFHR5 (NP_110414.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, K-562, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-569 of human CFHR5 (NP_110414.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GPPP SINN GDTT SFPL SVYP PGST VTYR CQSF YKLQ GSVT VTCR NKQW SEPP RCLD PCVV SEEN MNKN NIQL KWRN DGKL YAKT GDAV EFQC KFPH KAMI SSPP FRAI CQEG KFEY PICE |
| Gene ID: | 81494 |
| Uniprot: | Q9BXR6 |
| Cellular Location: | Secreted |
| Calculated MW: | 64kDa |
| Observed MW: | 75kDa |
| Synonyms: | CFHR5, CFHL5, CFHR5D, FHR-5, FHR5 |
| Background: | This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). |
| UniProt Protein Function: | CFHR5: Involved in complement regulation. Defects in CFHR5 have been found in patients with atypical hemolytic uremic syndrome and may contribute to the disease. Atypical hemolytic uremic syndrome is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1q31.3 Cellular Component: extracellular region Biological Process: complement activation, alternative pathway Disease: Cfhr5 Deficiency |
| NCBI Summary: | This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney Disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq] |
| UniProt Code: | Q9BXR6 |
| NCBI GenInfo Identifier: | 13540563 |
| NCBI Gene ID: | 81494 |
| NCBI Accession: | NP_110414.1 |
| UniProt Secondary Accession: | Q9BXR6,Q2NKK2, |
| UniProt Related Accession: | Q05CF5,Q5VYL6,Q9BXR6 |
| Molecular Weight: | 64,419 Da |
| NCBI Full Name: | complement factor H-related protein 5 |
| NCBI Synonym Full Names: | complement factor H-related 5 |
| NCBI Official Symbol: | CFHR5 |
| NCBI Official Synonym Symbols: | FHR5; CFHL5; FHR-5; FLJ10549; MGC133240 |
| NCBI Protein Information: | complement factor H-related protein 5; OTTHUMP00000034672 |
| UniProt Protein Name: | Complement factor H-related protein 5 |
| Protein Family: | Complement factor H-related protein |
| UniProt Gene Name: | CFHR5 |
| UniProt Entry Name: | FHR5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CFHR5 antibody (CAB10367) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
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