Cell Biology Antibodies 13

Anti-CENPN Antibody (CAB17731)

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SKU:
CAB17731
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CENPN Antibody
Antibody SKU:CAB17731
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human CENPN (NP_001094094).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HL-60, Mouse testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human CENPN (NP_001094094).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TIAS KHHQ IVKM DLRS RYLD SLKA IVFK QYNQ TFET HNST TPLQ ERSL GLDI NMDS RIIH ENIV EKER VQRI TQET FGDY PQPQ LEFA QYKL ETKF KSGL NGSI LAER EEPL RCLI KFSS P
Gene ID:55839
Uniprot:Q96H22
Cellular Location:
Calculated MW:
Observed MW:38kDa
Anti-CENPN Antibody (CAB17731)Western blot - CENPN Polyclonal Antibody (CAB17731)
Synonyms:BM039, C16orf60, CENP-N, ICEN32, CENPN
Background:The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
UniProt Protein Function:CENPN: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 16q23.2

Cellular Component: nucleoplasm; nucleus; cytosol

Biological Process: mitosis; nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; mitotic cell cycle; chromosome segregation

NCBI Summary:The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
UniProt Code:Q96H22
NCBI GenInfo Identifier:308153423
NCBI Gene ID:55839
NCBI Accession:Q96H22.2
UniProt Secondary Accession:Q96H22,Q9NZ83, A8MZE6, B3KN53, B4DJD1, B4DPY7, C9JJM5 D3DUK8, E7ES30, E7ETS3,
UniProt Related Accession:Q96H22
Molecular Weight:35,556 Da
NCBI Full Name:Centromere protein N
NCBI Synonym Full Names:centromere protein N
NCBI Official Symbol:CENPN  
NCBI Official Synonym Symbols:BM039; CENP-N; ICEN32; C16orf60  
NCBI Protein Information:centromere protein N; interphase centromere complex protein 32
UniProt Protein Name:Centromere protein N
UniProt Synonym Protein Names:Interphase centromere complex protein 32
Protein Family:Centromere protein
UniProt Gene Name:CENPN  
UniProt Entry Name:CENPN_HUMAN
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