Anti-CENPC Antibody (CAB3975)
- SKU:
- CAB3975
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CENP-C
- Synonyms:
- CENPC1
- Synonyms:
- MIF2
- Synonyms:
- hcp-4
- Research Area:
- Cell Cycle
Description
| Product Name: | CENPC Rabbit mAb |
| Product Code: | CAB3975 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CENP-C, CENPC1, MIF2, hcp-4 |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CENPC |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Jurkat |
| Immunogen: | A synthesized peptide derived from human CENPC |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1060 |
| Uniprot: | Q03188 |
| Calculated MW: | 107kDa |
| Observed MW: | 107KDa |
| UniProt Protein Function: | CENPC1: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. Belongs to the CENPC family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4q13.2 Cellular Component: centric heterochromatin; condensed nuclear chromosome, pericentric region; cytoplasm; cytosol; kinetochore; nucleoplasm; nucleus Molecular Function:DNA binding Biological Process: chromosome segregation; DNA replication-independent nucleosome assembly at centromere; kinetochore assembly; mitotic cell cycle; sister chromatid cohesion |
| NCBI Summary: | Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q03188 |
| NCBI GenInfo Identifier: | 296434446 |
| NCBI Gene ID: | 1060 |
| NCBI Accession: | Q03188.2 |
| UniProt Secondary Accession: | Q03188,Q6PIR0, Q8IW27, Q9P0M5, |
| UniProt Related Accession: | Q03188 |
| Molecular Weight: | 61,544 Da |
| NCBI Full Name: | Centromere protein C |
| NCBI Synonym Full Names: | centromere protein C |
| NCBI Official Symbol: | CENPC |
| NCBI Official Synonym Symbols: | MIF2; hcp-4; CENP-C; CENPC1 |
| NCBI Protein Information: | centromere protein C |
| UniProt Protein Name: | Centromere protein C |
| UniProt Synonym Protein Names: | Centromere autoantigen C; Centromere protein C 1; CENP-C 1; Interphase centromere complex protein 7 |
| Protein Family: | Centromere protein |
| UniProt Gene Name: | CENPC |
| UniProt Entry Name: | CENPC_HUMAN |
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