Cell Biology Antibodies 17
Anti-CELF5 Antibody (CAB18482)
- SKU:
- CAB18482
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-CELF5 Antibody |
Antibody SKU: | CAB18482 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IF |
Reactivity: | Human, Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant protein of human CELF5. |
Application: | WB IF |
Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse |
Positive Samples: | U-251MG, U-87MG, Mouse testis |
Immunogen: | Recombinant protein of human CELF5. |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 60680 |
Uniprot: | Q8N6W0 |
Cellular Location: | |
Calculated MW: | 44kDa/52kDa |
Observed MW: | 52kDa |
Synonyms: | BRUNOL-5, BRUNOL5, CELF-5, CELF5 |
Background: | This gene encodes a member of the the CELF/BRUNOL protein family, which contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing and translation. Alternatively spliced transcript variants have been found for this gene. |
UniProt Protein Function: | CELF5: RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Belongs to the CELF/BRUNOL family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19p13 |
NCBI Summary: | This gene encodes a member of the the CELF/BRUNOL protein family, which contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing and translation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] |
UniProt Code: | Q8N6W0 |
NCBI GenInfo Identifier: | 74762534 |
NCBI Gene ID: | 60680 |
NCBI Accession: | Q8N6W0.1 |
UniProt Secondary Accession: | Q8N6W0,O75253, Q59GP2, Q86VW6, Q9BZC0, Q9NR86, D6W614 |
UniProt Related Accession: | Q8N6W0 |
Molecular Weight: | 44,479 Da |
NCBI Full Name: | CUGBP Elav-like family member 5 |
NCBI Synonym Full Names: | CUGBP, Elav-like family member 5 |
NCBI Official Symbol: | CELF5 |
NCBI Official Synonym Symbols: | CELF-5; BRUNOL5; BRUNOL-5 |
NCBI Protein Information: | CUGBP Elav-like family member 5 |
UniProt Protein Name: | CUGBP Elav-like family member 5 |
UniProt Synonym Protein Names: | Bruno-like protein 5; CUG-BP- and ETR-3-like factor 5; RNA-binding protein BRUNOL-5 |
Protein Family: | CUGBP Elav-like family |
UniProt Gene Name: | CELF5 |
UniProt Entry Name: | CELF5_HUMAN |