Epigenetics & Nuclear Signaling Antibodies 2

Anti-CDX1 Antibody (CAB5712)

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SKU:
CAB5712
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-CDX1 Antibody
Antibody SKU:CAB5712
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 136-265 of human CDX1 (NP_001795.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:Mouse liver, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 136-265 of human CDX1 (NP_001795.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MRRS VAAG GGGG SGKT RTKD KYRV VYTD HQRL ELEK EFHY SRYI TIRR KSEL AANL GLTE RQVK IWFQ NRRA KERK VNKK KQQQ QQPP QPPM AHDI TATP AGPS LGGL CPSN TSLL ATSS PMPV KEEF LP
Gene ID:1044
Uniprot:P47902
Cellular Location:Nucleus
Calculated MW:14kDa/28kDa
Observed MW:35kDa
Synonyms:CDX1
Background:This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity.
UniProt Protein Function:CDX1: Could play a role in the terminal differentiation of the intestine. Belongs to the Caudal homeobox family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: nucleus

Molecular Function:protein binding

Biological Process: anterior/posterior axis specification; cell differentiation; organ morphogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of somitogenesis

NCBI Summary:This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008]
UniProt Code:P47902
NCBI GenInfo Identifier:116241291
NCBI Gene ID:1044
NCBI Accession:P47902.2
UniProt Secondary Accession:P47902,Q4VAU4, Q9NYK8,
UniProt Related Accession:P47902
Molecular Weight:14,661 Da
NCBI Full Name:Homeobox protein CDX-1
NCBI Synonym Full Names:caudal type homeobox 1
NCBI Official Symbol:CDX1  
NCBI Protein Information:homeobox protein CDX-1
UniProt Protein Name:Homeobox protein CDX-1
UniProt Synonym Protein Names:Caudal-type homeobox protein 1
Protein Family:Homeobox protein
UniProt Gene Name:CDX1  
UniProt Entry Name:CDX1_HUMAN
Anti-CDX1 Antibody (CAB5712)Western blot analysis of extracts of various cell lines, using CDX1 antibody (CAB5712) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-CDX1 Antibody (CAB5712)Immunohistochemistry of paraffin-embedded human colon using CDX1 antibody (CAB5712) at dilution of 1:100 (40x lens).
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