Epigenetics & Nuclear Signaling Antibodies 5
Anti-CDK8 Antibody (CAB9654)
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- SKU:
- CAB9654
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-CDK8 Antibody |
| Antibody SKU: | CAB9654 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CDK8 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Rat liver, Rat brain |
| Immunogen: | A synthesized peptide derived from human CDK8 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1024 |
| Uniprot: | P49336 |
| Cellular Location: | Nucleus |
| Calculated MW: | 53kDa |
| Observed MW: | 55KDa |
| Synonyms: | K35 |
| Background: | This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016] |
| UniProt Protein Function: | CDK8: a protein kinase of the CDK family. Along with cyclin C forms part of the RNA polymerase II holoenzyme complex. Phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. Regulates transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. |
| UniProt Protein Details: | Protein type:EC 2.7.11.23; Cell cycle regulation; EC 2.7.11.22; Protein kinase, CMGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CDK8 subfamily Chromosomal Location of Human Ortholog: 13q12 Cellular Component: nucleoplasm; Srb-mediator complex; nucleus Molecular Function:RNA polymerase subunit kinase activity; protein binding; cyclin-dependent protein kinase activity; ATP binding; protein kinase activity Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; transcription, DNA-dependent; regulation of cell cycle; transforming growth factor beta receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; gene expression; protein amino acid phosphorylation |
| NCBI Summary: | The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49336 |
| NCBI GenInfo Identifier: | 1345718 |
| NCBI Gene ID: | 1024 |
| NCBI Accession: | P49336.1 |
| UniProt Secondary Accession: | P49336,Q5VUF3, Q6ISB5, |
| UniProt Related Accession: | P49336 |
| Molecular Weight: | 464 |
| NCBI Full Name: | Cyclin-dependent kinase 8 |
| NCBI Synonym Full Names: | cyclin-dependent kinase 8 |
| NCBI Official Symbol: | CDK8 |
| NCBI Official Synonym Symbols: | K35 |
| NCBI Protein Information: | cyclin-dependent kinase 8; protein kinase K35; CDK8 protein kinase; mediator complex subunit CDK8; cell division protein kinase 8; mediator of RNA polymerase II transcription subunit CDK8 |
| UniProt Protein Name: | Cyclin-dependent kinase 8 |
| UniProt Synonym Protein Names: | Cell division protein kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; Protein kinase K35 |
| Protein Family: | Cyclin-dependent kinase |
| UniProt Gene Name: | CDK8 |
| UniProt Entry Name: | CDK8_HUMAN |
 | Western blot - CDK8 Rabbit mAb (CAB9654) |
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