Epigenetics & Nuclear Signaling Antibodies 2
Anti-CDK5RAP1 Antibody (CAB15844)
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- SKU:
- CAB15844
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-CDK5RAP1 Antibody |
| Antibody SKU: | CAB15844 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human CDK5RAP1 (NP_057492.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human CDK5RAP1 (NP_057492.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MHPL QCVL QVQR SLGW GPLA SVSW LSLR MCRA HSSL SSTM CPSP ERQE DGAR KDFS SRLA AGPT FQHF LKSA SAPQ EKLS SEVE DPPP YLMM DELL GRQR KVYL ETYG CQMN VNDT EIAW SILQ KSGY LRTS NLQE ADVI LLVT CSIR EKAE QTIW NRLH QLKA LKTR RPRS RVPL RIGI LGCM AERL KEEI LNRE KMVD ILAG PDAY RDLP RLLA VAES GQQA ANVL LSLD ETYA DVMP VQTS ASAT SAFV SIMR GCDN MCSY CIVP FTRG RERS RPIA SILE EVKK LSEQ GLKE VTLL GQNV NSFR DNSE VQFN SAVP TNLS RGFT TNYK TKQG GLRF AHLL DQVS RV |
| Gene ID: | 51654 |
| Uniprot: | Q96SZ6 |
| Cellular Location: | |
| Calculated MW: | 48kDa/56kDa/57kDa/64kDa/66kDa/67kDa |
| Observed MW: | 68kDa |
| Synonyms: | CDK5RAP1, C20orf34, C42, CGI-05, HSPC167 |
| Background: | This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. |
| UniProt Protein Function: | CDK5RAP1: Specifically inhibits CDK5 activation by CDK5R1. Belongs to the methylthiotransferase family. MiaB subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 20q11.21 Molecular Function:4 iron, 4 sulfur cluster binding; protein kinase regulator activity Biological Process: negative regulation of cyclin-dependent protein kinase activity |
| NCBI Summary: | This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013] |
| UniProt Code: | Q96SZ6 |
| NCBI GenInfo Identifier: | 32129446 |
| NCBI Gene ID: | 51654 |
| NCBI Accession: | Q96SZ6.2 |
| UniProt Secondary Accession: | Q96SZ6,Q5QP46, Q5QP47, Q5QP48, Q675N4, Q675N5, Q9BVG6 Q9BWZ5, Q9H859, Q9NZZ9, Q9Y3F0, A8K7R0, |
| UniProt Related Accession: | Q96SZ6 |
| Molecular Weight: | 64,709 Da |
| NCBI Full Name: | CDK5 regulatory subunit-associated protein 1 |
| NCBI Synonym Full Names: | CDK5 regulatory subunit associated protein 1 |
| NCBI Official Symbol: | CDK5RAP1 |
| NCBI Official Synonym Symbols: | C42; CGI-05; HSPC167; C20orf34 |
| NCBI Protein Information: | CDK5 regulatory subunit-associated protein 1 |
| UniProt Protein Name: | CDK5 regulatory subunit-associated protein 1 |
| UniProt Synonym Protein Names: | CDK5 activator-binding protein C42 |
| Protein Family: | CDK5RAP1-like protein |
| UniProt Gene Name: | CDK5RAP1 |
| UniProt Entry Name: | CK5P1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDK5RAP1 antibody (CAB15844) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat liver using CDK5RAP1 antibody (CAB15844) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using CDK5RAP1 antibody (CAB15844) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using CDK5RAP1 antibody (CAB15844) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using CDK5RAP1 antibody (CAB15844) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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