Cell Biology Antibodies 2
Anti-CDH4 Antibody (CAB10557)
(No reviews yet)
Write a Review
- SKU:
- CAB10557
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CDH4 Antibody |
| Antibody SKU: | CAB10557 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 757-916 of human CDH4 (NP_001785.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Mouse brain, Mouse thymus, Rat brain, Rat skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 757-916 of human CDH4 (NP_001785.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KRRE KERH TKQL LIDP EDDV RDNI LKYD EEGG GEED QDYD LSQL QQPE AMGH VPSK APGV RRVD ERPV GAEP QYPI RPMV PHPG DIGD FINE GLRA ADND PTAP PYDS LLVF DYEG SGST AGSV SSLN SSSS GDQD YDYL NDWG PRFK KLAD MYGG GEED |
| Gene ID: | 1002 |
| Uniprot: | P55283 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 92kDa/100kDa |
| Observed MW: | 100kDa/115kDa |
| Synonyms: | CDH4, CAD4, R-CAD, RCAD |
| Background: | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CDH4: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. Expressed mainly in brain but also found in other tissues. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 20q13.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:calcium ion binding Biological Process: heterophilic cell adhesion; intercellular junction assembly and maintenance; axon guidance; positive regulation of axon extension; cell adhesion; homophilic cell adhesion |
| NCBI Summary: | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | P55283 |
| NCBI GenInfo Identifier: | 81175161 |
| NCBI Gene ID: | 1002 |
| NCBI Accession: | P55283.2 |
| UniProt Secondary Accession: | P55283,Q2M208, Q5VZ44, Q9BZ05, B3KWB8, G3V1P8, |
| UniProt Related Accession: | P55283 |
| Molecular Weight: | 92,388 Da |
| NCBI Full Name: | Cadherin-4 |
| NCBI Synonym Full Names: | cadherin 4, type 1, R-cadherin (retinal) |
| NCBI Official Symbol: | CDH4 |
| NCBI Official Synonym Symbols: | CAD4; RCAD; R-CAD |
| NCBI Protein Information: | cadherin-4; R-cadherin; cadherin 4, type 1, preproprotein; retinal cadherin |
| UniProt Protein Name: | Cadherin-4 |
| UniProt Synonym Protein Names: | Retinal cadherin; R-CAD; R-cadherin |
| UniProt Gene Name: | CDH4 |
| UniProt Entry Name: | CADH4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDH4 antibody (CAB10557) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
View AllClose
Related Products
Human R-Cadherin/CDH4 Recombinant Protein (RPES5044)
system_update_altDatasheetHuman R-Cadherin/CDH4 Recombinant Protein The cadherin superfamily is a large family that engage in both homo- and heterotypic, calcium-dependent, cell-cell adhesion eve
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
Human Anti-DSG3 antibody(anti-Desmoglein-3 antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
