Anti-CDC23 Antibody (CAB6025)
- SKU:
- CAB6025
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ANAPC8
- Synonyms:
- APC8
- Synonyms:
- CUT23
- Research Area:
- Cell Cycle
Description
| Product Name: | CDC23 Rabbit mAb |
| Product Code: | CAB6025 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ANAPC8, APC8, CUT23 |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CDC23 |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, SKOV3, Jurkat, Mouse lung, Mouse brain, Mouse spleen, Rat brain |
| Immunogen: | A synthesized peptide derived from human CDC23 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8697 |
| Uniprot: | Q9UJX2 |
| Calculated MW: | 64kDa |
| Observed MW: | 69KDa |
| UniProt Protein Function: | CDC23: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC8/CDC23 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 5q31 Cellular Component: nucleoplasm; anaphase-promoting complex; intracellular; cytosol Molecular Function:ubiquitin-protein ligase activity Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; ubiquitin-dependent protein catabolic process; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; regulation of mitotic metaphase/anaphase transition; mitotic cell cycle spindle assembly checkpoint; regulation of exit from mitosis; mitotic cell cycle; mitotic metaphase plate congression; mitotic metaphase/anaphase transition |
| NCBI Summary: | The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UJX2 |
| NCBI GenInfo Identifier: | 254763423 |
| NCBI Gene ID: | 8697 |
| NCBI Accession: | Q9UJX2.3 |
| UniProt Secondary Accession: | Q9UJX2,O75433, Q53FN2, Q9BS73, A8K6E5, B4E3A2, B7WP05 D3DQB7, |
| UniProt Related Accession: | Q9UJX2 |
| Molecular Weight: | 55,882 Da |
| NCBI Full Name: | Cell division cycle protein 23 homolog |
| NCBI Synonym Full Names: | cell division cycle 23 |
| NCBI Official Symbol: | CDC23 |
| NCBI Official Synonym Symbols: | APC8; CUT23; ANAPC8 |
| NCBI Protein Information: | cell division cycle protein 23 homolog; cyclosome subunit 8; cell division cycle 23 homolog; anaphase promoting complex subunit 8; anaphase-promoting complex subunit 8 |
| UniProt Protein Name: | Cell division cycle protein 23 homolog |
| UniProt Synonym Protein Names: | Anaphase-promoting complex subunit 8; APC8; Cyclosome subunit 8 |
| Protein Family: | Anaphase-promoting complex |
| UniProt Gene Name: | CDC23 |
| UniProt Entry Name: | CDC23_HUMAN |
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