Anti-CD96 Antibody (CAB20547)

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SKU:
CAB20547
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TACTILE

Description

Product Name:CD96 Rabbit pAb
Product Code:CAB20547
Size:50uL, 100uL
Synonyms:TACTILE
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 270-370 of human CD96 (NP_937839.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 270-370 of human CD96 (NP_937839.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10225
Uniprot:P40200
Calculated MW:65kDa
Observed MW:Refer to figures
UniProt Protein Function:CD96: May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation. Defects in CD96 are a cause of C syndrome (CSYN); also called Opitz trigonocephaly syndrome. This syndrome is characterized by trigonocephaly and associated anomalies, such as unusual facies, wide alveolar ridges, multiple buccal frenula, limb defects, visceral anomalies, redundant skin, psychomotor retardation and hypotonia. A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 3q13.13-q13.2 Cellular Component: integral to plasma membrane; plasma membrane Biological Process: cell adhesion; immune response; regulation of immune response Disease: C Syndrome
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
UniProt Code:P40200
NCBI GenInfo Identifier:161784352
NCBI Gene ID:10225
NCBI Accession:P40200.2
UniProt Secondary Accession:P40200,Q5JPB3
UniProt Related Accession:P40200
Molecular Weight:
NCBI Full Name:T-cell surface protein tactile
NCBI Synonym Full Names:CD96 molecule
NCBI Official Symbol:CD96  
NCBI Official Synonym Symbols:TACTILE  
NCBI Protein Information:T-cell surface protein tactile
UniProt Protein Name:T-cell surface protein tactile
UniProt Synonym Protein Names:Cell surface antigen CD96; T cell-activated increased late expression protein; CD_antigen: CD96
Protein Family:T-cell surface protein tactile
UniProt Gene Name:CD96  
UniProt Entry Name:TACT_HUMAN
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