Immunology Antibodies 3
Anti-CD6 Antibody (CAB8107)
- SKU:
- CAB8107
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | CD6 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8107 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 424-668 of human CD6 (NP_006716.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | MCF7, Jurkat, U-937, HT-29, Raji |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 424-668 of human CD6 (NP_006716.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LRIK GKYA LPVM VNHQ HLPT TIPA GSNS YQPV PITI PKEV FMLP IQVQ APPP EDSD SGSD SDYE HYDF SAQP PVAL TTFY NSQR HRVT DEEV QQSR FQMP PLEE GLEE LHAS HIPT ANPG HCIT DPPS LGPQ YHPR SNSE SSTS SGED YCNS PKSK LPPW NPQV FSSE RSSF LEQP PNLE LAGT QPAF SAGP PADD SSST SSGE WYQN FQPP PQPP SEEQ FGCP GSPS PQPD STDN DDYD DISA A |
| Gene ID: | 923 |
| Uniprot: | P30203 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 58kDa/60kDa/63kDa/64kDa/68kDa/71kDa |
| Observed MW: | 110kDa |
| Synonyms: | CD6, TP120 |
| Background: | This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CD6: a type I membrane protein involved in cell adhesion. Binds to CD166. Expressed on thymocytes, peripheral T cells, a subset of B cells, and a subset of neurons. Mediates the binding of developing thymocytes with thymic epithelial cells. CD6- T cells are less autoreactive than CD6+ T cells. Phosphorylated on tyrosines and serines following T cell antigen receptor signaling. Five splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q13 Cellular Component: integral to plasma membrane Molecular Function:protein binding; scavenger receptor activity Biological Process: receptor-mediated endocytosis; cell adhesion |
| NCBI Summary: | This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | P30203 |
| NCBI GenInfo Identifier: | 281185506 |
| NCBI Gene ID: | 923 |
| NCBI Accession: | P30203.3 |
| UniProt Secondary Accession: | P30203,Q9UMF2, Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0, A4KAD4 A4KAD5, |
| UniProt Related Accession: | P30203 |
| Molecular Weight: | 60,572 Da |
| NCBI Full Name: | T-cell differentiation antigen CD6 |
| NCBI Synonym Full Names: | CD6 molecule |
| NCBI Official Symbol: | CD6 |
| NCBI Official Synonym Symbols: | TP120 |
| NCBI Protein Information: | T-cell differentiation antigen CD6; T12; CD6 antigen |
| UniProt Protein Name: | T-cell differentiation antigen CD6 |
| UniProt Synonym Protein Names: | T12; TP120; CD_antigen: CD6 |
| Protein Family: | T-cell differentiation antigen |
| UniProt Gene Name: | CD6 |
| UniProt Entry Name: | CD6_HUMAN |
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