Cell Biology Antibodies 16

Anti-CD41 Antibody (CAB11490)

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SKU:
CAB11490
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CD41 Antibody
Antibody SKU:CAB11490
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CD41
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, PC-3, K-562, Mouse spleen, Rat brain, Rat heart
Immunogen:A synthesized peptide derived from human CD41
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3674
Uniprot:P08514
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:135kDa
Observed MW:137KDa
Anti-CD41 AntibodyWestern blot - CD41 Rabbit mAb (CAB11490)
Synonyms:BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93
Background:This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]
UniProt Protein Function:ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; platelet alpha granule membrane

Molecular Function:identical protein binding; protein binding

Biological Process: cell adhesion; extracellular matrix organization and biogenesis; integrin-mediated signaling pathway; platelet degranulation

Disease: Bleeding Disorder, Platelet-type, 16; Glanzmann Thrombasthenia

NCBI Summary:This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]
UniProt Code:P08514
NCBI GenInfo Identifier:226694183
NCBI Gene ID:3674
NCBI Accession:P08514.3
UniProt Secondary Accession:P08514,O95366, Q14443, Q17R67, B2RCY8,
UniProt Related Accession:P08514
Molecular Weight:113kDa
NCBI Full Name:Integrin alpha-IIb
NCBI Synonym Full Names:integrin subunit alpha 2b
NCBI Official Symbol:ITGA2B  
NCBI Official Synonym Symbols:GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93  
NCBI Protein Information:integrin alpha-IIb
UniProt Protein Name:Integrin alpha-IIb
UniProt Synonym Protein Names:GPalpha IIb; GPIIb
Protein Family:Integrin
UniProt Gene Name:ITGA2B  
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