Cell Biology Antibodies 7

Anti-CD28 Antibody (CAB17447)

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SKU:
CAB17447
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CD28 Antibody
Antibody SKU:CAB17447
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human CD28.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HL-60, Raji, Mouse spleen, Rat spleen, Rat kidney, Rat thymus
Immunogen:Recombinant protein of human CD28.
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:940
Uniprot:P10747
Cellular Location:
Calculated MW:25kDa
Observed MW:50kDa/60kDa
Synonyms:CD28, Tp44
Background:The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).
NCBI Summary:The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
UniProt Code:P10747
NCBI GenInfo Identifier:115973
NCBI Gene ID:940
NCBI Accession:P10747.1
UniProt Secondary Accession:P10747,Q13964, Q52M23, Q70WG0, Q8NI54, Q8NI55, Q8NI56 Q8WXJ2, Q9BYV0, A8KAC1,
UniProt Related Accession:P10747
Molecular Weight:26,186 Da
NCBI Full Name:T-cell-specific surface glycoprotein CD28
NCBI Synonym Full Names:CD28 molecule
NCBI Official Symbol:CD28  
NCBI Official Synonym Symbols:Tp44  
NCBI Protein Information:T-cell-specific surface glycoprotein CD28
UniProt Protein Name:T-cell-specific surface glycoprotein CD28
UniProt Synonym Protein Names:TP44; CD_antigen: CD28
Protein Family:T-cell-specific surface glycoprotein
UniProt Gene Name:CD28  
Anti-CD28 Antibody (CAB17447)Western blot analysis of extracts of various cell lines, using CD28 antibody (CAB17447) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
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