Immunology Antibodies 2

Anti-CD244 Antibody (CAB1993)

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SKU:
CAB1993
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:Anti-CD244 Antibody
Antibody SKU:CAB1993
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-224 of human CD244 (NP_057466.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Jurkat, 293T, Mouse spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-224 of human CD244 (NP_057466.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CQGS ADHV VSIS GVPL QLQP NSIQ TKVD SIAW KKLL PSQN GFHH ILKW ENGS LPSN TSND RFSF IVKN LSLL IKAA QQQD SGLY CLEV TSIS GKVQ TATF QVFV FDKV EKPR LQGQ GKIL DRGR CQVA LSCL VSRD GNVS YAWY RGSK LIQT AGNL TYLD EEVD INGT HTYT CNVS NPVS WESH TLNL TQDC QNAH QEFR FWP
Gene ID:51744
Uniprot:Q9BZW8
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:30kDa/36kDa/41kDa
Observed MW:36kDa
Synonyms:CD244, 2B4, NAIL, NKR2B4, Nmrk, SLAMF4
Background:This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:CD244: Modulate other receptor-ligand interactions to enhance leukocyte activation. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function:protein binding; receptor activity

Biological Process: signal transduction; blood coagulation; leukocyte migration

Disease: Rheumatoid Arthritis

NCBI Summary:This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
UniProt Code:Q9BZW8
NCBI GenInfo Identifier:47605541
NCBI Gene ID:51744
NCBI Accession:Q9BZW8.2
UniProt Related Accession:Q9BZW8
Molecular Weight:
NCBI Full Name:
NCBI Synonym Full Names:CD244 molecule
NCBI Official Symbol:CD244  
NCBI Official Synonym Symbols:2B4; NAIL; Nmrk; NKR2B4; SLAMF4  
NCBI Protein Information:natural killer cell receptor 2B4
UniProt Protein Name:Natural killer cell receptor 2B4
UniProt Synonym Protein Names:NK cell activation-inducing ligand; NAIL; NK cell type I receptor protein 2B4; NKR2B4; h2B4; SLAM family member 4; SLAMF4; Signaling lymphocytic activation molecule 4; CD_antigen: CD244
UniProt Gene Name:CD244  
UniProt Entry Name:CD244_HUMAN
Anti-CD244 Antibody (CAB1993)Western blot analysis of extracts of various cell lines, using CD244 antibody (CAB1993) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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