Immunology Antibodies 2

Anti-CD1B Antibody (CAB6551)

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SKU:
CAB6551
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-CD1B Antibody
Antibody SKU:CAB6551
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 18-303 of human CD1B (NP_001755.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:NCI-H125
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 18-303 of human CD1B (NP_001755.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SEHA FQGP TSFH VIQT SSFT NSTW AQTQ GSGW LDDL QIHG WDSD SGTA IFLK PWSK GNFS DKEV AELE EIFR VYIF GFAR EVQD FAGD FQMK YPFE IQGI AGCE LHSG GAIV SFLR GALG GLDF LSVK NASC VPSP EGGS RAQK FCAL IIQY QGIM ETVR ILLY ETCP RYLL GVLN AGKA DLQR QVKP EAWL SSGP SPGP GRLQ LVCH VSGF YPKP VWVM WMRG EQEQ QGTQ LGDI LPNA NWTW YLRA TLDV ADGE AAGL SCRV KHSS LEGQ DIIL YWRN PTSI GS
Gene ID:910
Uniprot:P29016
Cellular Location:Cell membrane, Endosome membrane, Lysosome membrane, Single-pass type I membrane protein
Calculated MW:30kDa/36kDa
Observed MW:47kDa
Synonyms:CD1B, CD1, CD1A, R1
Background:This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens.
UniProt Protein Function:CD1B: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: cell surface; plasma membrane

Molecular Function:beta-2-microglobulin binding; endogenous lipid antigen binding; exogenous lipid antigen binding; protein binding

Biological Process: antigen processing and presentation, exogenous lipid antigen via MHC class Ib; regulation of immune response

NCBI Summary:This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008]
UniProt Code:P29016
NCBI GenInfo Identifier:115962
NCBI Gene ID:910
NCBI Accession:P29016.1
UniProt Secondary Accession:P29016,Q5TDK9, Q5TDL0, Q9UMM2,
UniProt Related Accession:P29016
Molecular Weight:30,740 Da
NCBI Full Name:T-cell surface glycoprotein CD1b
NCBI Synonym Full Names:CD1b molecule
NCBI Official Symbol:CD1B  
NCBI Official Synonym Symbols:R1; CD1; CD1A  
NCBI Protein Information:T-cell surface glycoprotein CD1b
UniProt Protein Name:T-cell surface glycoprotein CD1b
UniProt Synonym Protein Names:CD_antigen: CD1b
Protein Family:T-cell surface glycoprotein
UniProt Gene Name:CD1B  
UniProt Entry Name:CD1B_HUMAN
Anti-CD1B Antibody (CAB6551)Western blot analysis of extracts of NCI-H125 cells, using CD1B Antibody (CAB6551) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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