Name: Anti-CD168[KO Validated] Antibody (CAB11666)
Brand: KO Validated Antibodies 1
SKU: CAB11666
Availability: OutOfStock

Antibody Name:	Anti-CD168[KO Validated] Antibody
Antibody SKU:	CAB11666
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human CD168

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse
Positive Samples:	HeLa, K-562

Immunogen:	A synthesized peptide derived from human CD168
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	3161
Uniprot:	O75330
Cellular Location:	Cell surface, Cytoplasm
Calculated MW:	85kDa
Observed MW:	84KDa

	Western blot analysis of extracts from normal (control) and CD168 knockout (KO) HeLa cells, using CD168 Rabbit mAb (CAB11666) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min.
	Western blot analysis of extracts of K-562 cells, using CD168 Rabbit mAb (CAB11666) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min.
	Immunohistochemistry of paraffin-embedded mouse kidney using [KO Validated] CD168 Rabbit mAb (CAB11666) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human esophageal using [KO Validated] CD168 Rabbit mAb (CAB11666) at dilution of 1:100 (40x lens).

Synonyms:	CD168, IHABP, RHAMM
Background:	The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]

UniProt Protein Function:	HMMR: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Receptor, misc. Chromosomal Location of Human Ortholog: 5q34 Cellular Component: cell surface; membrane; cytoplasm; plasma membrane Molecular Function:hyaluronic acid binding Biological Process: glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis; hyaluronan metabolic process; hyaluronan catabolic process Disease: Breast Cancer
NCBI Summary:	The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]
UniProt Code:	O75330
NCBI GenInfo Identifier:	145559482
NCBI Gene ID:	3161
NCBI Accession:	O75330.2
UniProt Secondary Accession:	O75330,Q32N02, Q92767, A8K3G2, B4E114, D3DQK9, D3DQL0 E9PCS0,
UniProt Related Accession:	O75330
Molecular Weight:
NCBI Full Name:	Hyaluronan mediated motility receptor
NCBI Synonym Full Names:	hyaluronan-mediated motility receptor (RHAMM)
NCBI Official Symbol:	HMMR
NCBI Official Synonym Symbols:	CD168; IHABP; RHAMM
NCBI Protein Information:	hyaluronan mediated motility receptor; receptor for hyaluronan-mediated motility; intracellular hyaluronic acid-binding protein
UniProt Protein Name:	Hyaluronan mediated motility receptor
UniProt Synonym Protein Names:	Intracellular hyaluronic acid-binding protein; Receptor for hyaluronan-mediated motility; CD_antigen: CD168
Protein Family:	Hyaluronan mediated motility receptor
UniProt Gene Name:	HMMR
UniProt Entry Name:	HMMR_HUMAN

Antibodies	ELISA Kits
Anti-HMMR Antibody (CAB12445)[KO Validated]	Human RHAMM / CD168 ELISA Kit
HMMR Antibody (PACO04054)	Human Hyaluronan mediated motility receptor (HMMR) ELISA Kit
HMMR Antibody (PACO07350)

Secondary Antibody

Anti-HRP Goat Anti-Mouse IgG (H+L) Antibody (CABS003)