KO Validated Antibodies 1
Anti-CD168[KO Validated] Antibody (CAB11666)
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![Anti-CD168[KO Validated] Antibody (CAB11666)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/54164/58907/anti-cd168ko-validated-antibody-cab11666__68291__88532.1706528643.jpg?c=1 "Anti-CD168[KO Validated] Antibody (CAB11666)")
- SKU:
- CAB11666
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
![Anti-CD168[KO Validated] Antibody (CAB11666)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/54164/58907/anti-cd168ko-validated-antibody-cab11666__68291__88532.1706528643.jpg?c=1&imbypass=on "Anti-CD168[KO Validated] Antibody (CAB11666)")
Description
| Antibody Name: | Anti-CD168[KO Validated] Antibody |
| Antibody SKU: | CAB11666 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CD168 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, K-562 |
| Immunogen: | A synthesized peptide derived from human CD168 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3161 |
| Uniprot: | O75330 |
| Cellular Location: | Cell surface, Cytoplasm |
| Calculated MW: | 85kDa |
| Observed MW: | 84KDa |
![Anti-CD168[KO Validated] Antibody](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/q/630/A11666_1__72191.jpg) | Western blot analysis of extracts from normal (control) and CD168 knockout (KO) HeLa cells, using CD168 Rabbit mAb (CAB11666) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min. |
![Anti-CD168[KO Validated] Antibody](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/z/268/A11666_2__04458.jpg) | Western blot analysis of extracts of K-562 cells, using CD168 Rabbit mAb (CAB11666) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min. |
![Anti-CD168[KO Validated] Antibody](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/v/202/A11666_3__93963.jpg) | Immunohistochemistry of paraffin-embedded mouse kidney using [KO Validated] CD168 Rabbit mAb (CAB11666) at dilution of 1:100 (40x lens). |
![Anti-CD168[KO Validated] Antibody](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/o/422/A11666_4__90484.jpg) | Immunohistochemistry of paraffin-embedded human esophageal using [KO Validated] CD168 Rabbit mAb (CAB11666) at dilution of 1:100 (40x lens). |
| Synonyms: | CD168, IHABP, RHAMM |
| Background: | The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008] |
| UniProt Protein Function: | HMMR: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc. Chromosomal Location of Human Ortholog: 5q34 Cellular Component: cell surface; membrane; cytoplasm; plasma membrane Molecular Function:hyaluronic acid binding Biological Process: glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis; hyaluronan metabolic process; hyaluronan catabolic process Disease: Breast Cancer |
| NCBI Summary: | The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008] |
| UniProt Code: | O75330 |
| NCBI GenInfo Identifier: | 145559482 |
| NCBI Gene ID: | 3161 |
| NCBI Accession: | O75330.2 |
| UniProt Secondary Accession: | O75330,Q32N02, Q92767, A8K3G2, B4E114, D3DQK9, D3DQL0 E9PCS0, |
| UniProt Related Accession: | O75330 |
| Molecular Weight: | |
| NCBI Full Name: | Hyaluronan mediated motility receptor |
| NCBI Synonym Full Names: | hyaluronan-mediated motility receptor (RHAMM) |
| NCBI Official Symbol: | HMMR |
| NCBI Official Synonym Symbols: | CD168; IHABP; RHAMM |
| NCBI Protein Information: | hyaluronan mediated motility receptor; receptor for hyaluronan-mediated motility; intracellular hyaluronic acid-binding protein |
| UniProt Protein Name: | Hyaluronan mediated motility receptor |
| UniProt Synonym Protein Names: | Intracellular hyaluronic acid-binding protein; Receptor for hyaluronan-mediated motility; CD_antigen: CD168 |
| Protein Family: | Hyaluronan mediated motility receptor |
| UniProt Gene Name: | HMMR |
| UniProt Entry Name: | HMMR_HUMAN |
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