Cell Biology Antibodies 5

Anti-CCR7 Antibody (CAB14718)

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SKU:
CAB14718
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CCR7 Antibody
Antibody SKU:CAB14718
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CCR7 (NP_001829.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Jurkat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CCR7 (NP_001829.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDLG KPMK SVLV VALL VIFQ VCLC QDEV TDDY IGDN TTVD YTLF ESLC SKKD VRNF KAWF LPIM YSII CFVG LLGN GLVV LTYI YFKR LKTM TDTY LLNL
Gene ID:1236
Uniprot:P32248
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:42kDa
Observed MW:45kDa
Synonyms:CCR7, BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1
Background:The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.
UniProt Protein Function:CCR7: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q12-q21.2

Cellular Component: cell surface; plasma membrane; integral to membrane; intracellular; external side of plasma membrane

Molecular Function:G-protein coupled receptor activity; C-C chemokine receptor activity

Biological Process: positive regulation of cell adhesion; positive regulation of interleukin-12 production; positive regulation of dendritic cell antigen processing and presentation; positive regulation of JNK cascade; response to lipopolysaccharide; elevation of cytosolic calcium ion concentration; positive regulation of T cell receptor signaling pathway; positive regulation of humoral immune response; dendritic cell chemotaxis; establishment of T cell polarity; positive regulation of cell-matrix adhesion; inflammatory response; positive regulation of filopodium formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of hypersensitivity; positive regulation of phosphoinositide 3-kinase activity; negative thymic T cell selection; positive regulation of protein kinase B signaling cascade; G-protein coupled receptor protein signaling pathway; myeloid dendritic cell chemotaxis; positive regulation of pseudopodium formation; positive regulation of actin filament polymerization; regulation of interferon-gamma production; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; ruffle organization and biogenesis; regulation of interleukin-1 beta secretion; immune response

NCBI Summary:The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
UniProt Code:P32248
NCBI GenInfo Identifier:1352335
NCBI Gene ID:1236
NCBI Accession:P32248.2
UniProt Related Accession:P32248
Molecular Weight:378
NCBI Full Name:C-C chemokine receptor type 7
NCBI Synonym Full Names:chemokine (C-C motif) receptor 7
NCBI Official Symbol:CCR7  
NCBI Official Synonym Symbols:BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7  
NCBI Protein Information:C-C chemokine receptor type 7; MIP-3 beta receptor; CC chemokine receptor 7; Bukitt's lymphoma receptor 2; Epstein-Barr virus induced gene 1; EBV-induced G protein-coupled receptor 1; lymphocyte-specific G protein-coupled peptide receptor; Epstein-Barr virus-induced G-protein coupled receptor 1
UniProt Protein Name:C-C chemokine receptor type 7
UniProt Synonym Protein Names:BLR2; CDw197; Epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; EBV-induced G-protein coupled receptor 1; MIP-3 beta receptor; CD_antigen: CD197
Protein Family:C-C chemokine receptor
UniProt Gene Name:CCR7  
UniProt Entry Name:CCR7_HUMAN
Anti-CCR7 Antibody (CAB14718)Western blot analysis of extracts of Jurkat cells, using CCR7 antibody (CAB14718) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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