Immunology Antibodies 2

Anti-CCR6 Antibody (CAB16206)

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SKU:
CAB16206
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-CCR6 Antibody
Antibody SKU:CAB16206
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human CCR6 (NP_004358.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:LO2
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human CCR6 (NP_004358.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VTEV LAFL HCCL NPVL YAFI GQKF RNYF LKIL KDLW CVRR KYKS SGFS CAGR YSEN ISRQ TSET ADND NASS FTM
Gene ID:1235
Uniprot:P51684
Cellular Location:
Calculated MW:42kDa
Observed MW:52kDa
Synonyms:CCR6, BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22
Background:This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.
UniProt Protein Function:CCR6: Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Receptor, GPCR; Membrane protein, integral; Motility/polarity/chemotaxis; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: cell surface; cytosol; integral to plasma membrane; plasma membrane

Molecular Function:C-C chemokine receptor activity; chemokine receptor activity; receptor activity

Biological Process: cell motility; cellular defense response; chemotaxis; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; humoral immune response; immune response; innate immune response; signal transduction

NCBI Summary:This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P51684
NCBI GenInfo Identifier:2851567
NCBI Gene ID:1235
NCBI Accession:P51684.2
UniProt Secondary Accession:P51684,P78553, Q92846, E1P5C6,
UniProt Related Accession:P51684
Molecular Weight:42,494 Da
NCBI Full Name:C-C chemokine receptor type 6
NCBI Synonym Full Names:C-C motif chemokine receptor 6
NCBI Official Symbol:CCR6  
NCBI Official Synonym Symbols:BN-1; DCR2; DRY6; CCR-6; CD196; CKRL3; GPR29; CKR-L3; CMKBR6; GPRCY4; STRL22; CC-CKR-6; C-C CKR-6  
NCBI Protein Information:C-C chemokine receptor type 6
UniProt Protein Name:C-C chemokine receptor type 6
UniProt Synonym Protein Names:Chemokine receptor-like 3; CKR-L3; DRY6; G-protein coupled receptor 29; GPR-CY4; GPRCY4; LARC receptor; CD_antigen: CD196
Protein Family:C-C chemokine receptor
UniProt Gene Name:CCR6  
UniProt Entry Name:CCR6_HUMAN
Anti-CCR6 Antibody (CAB16206)Western blot analysis of extracts of LO2 cells, using CCR6 antibody (CAB16206) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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