Immunology Antibodies 2
Anti-CCR4 Antibody (CAB17324)
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- SKU:
- CAB17324
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-CCR4 Antibody |
| Antibody SKU: | CAB17324 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CCR4 (NP_005499.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CCR4 (NP_005499.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNPT DIAD TTLD ESIY SNYY LYES IPKP CTKE GIKA FGEL FLPP LYSL VFVF GLLG NSVV VLVL FKYK RLRS MTDV YLLN LAIS DLLF VFSL PFWG YYAA |
| Gene ID: | 1233 |
| Uniprot: | P51679 |
| Cellular Location: | |
| Calculated MW: | 41kDa |
| Observed MW: | Refer to figures |
| Synonyms: | CCR4, CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5 |
| Background: | The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. |
| UniProt Protein Function: | CCR4: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1 Chromosomal Location of Human Ortholog: 3p24 Cellular Component: cell soma; integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:C-C chemokine receptor activity; chemokine receptor activity Biological Process: response to antibiotic; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; response to radiation; positive regulation of positive chemotaxis; response to bacterium; neuron migration; immune response; inflammatory response; chemotaxis; tolerance induction |
| NCBI Summary: | The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51679 |
| NCBI GenInfo Identifier: | 1705894 |
| NCBI Gene ID: | 1233 |
| NCBI Accession: | P51679.1 |
| UniProt Secondary Accession: | P51679,Q9ULY6, Q9ULY7, |
| UniProt Related Accession: | P51679 |
| Molecular Weight: | 41,403 Da |
| NCBI Full Name: | C-C chemokine receptor type 4 |
| NCBI Synonym Full Names: | chemokine (C-C motif) receptor 4 |
| NCBI Official Symbol: | CCR4 |
| NCBI Official Synonym Symbols: | CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099 |
| NCBI Protein Information: | C-C chemokine receptor type 4; C-C CKR-4; CCR-4; chemokine (C-C) receptor 4 |
| UniProt Protein Name: | C-C chemokine receptor type 4 |
| UniProt Synonym Protein Names: | K5-5; CD_antigen: CD194 |
| Protein Family: | C-C chemokine receptor |
| UniProt Gene Name: | CCR4 |
| UniProt Entry Name: | CCR4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CCR4 antibody (CAB17324) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 120s. |
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