Cell Biology Antibodies 10
Anti-CCL8 Antibody (CAB6977)
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- SKU:
- CAB6977
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CCL8 Antibody |
| Antibody SKU: | CAB6977 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-99 of human CCL8 (NP_005614.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-99 of human CCL8 (NP_005614.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AQPD SVSI PITC CFNV INRK IPIQ RLES YTRI TNIQ CPKE AVIF KTKR GKEV CADP KERW VRDS MKHL DQIF QNLK P |
| Gene ID: | 6355 |
| Uniprot: | P80075 |
| Cellular Location: | Secreted |
| Calculated MW: | 11kDa |
| Observed MW: | Refer to figures |
| Synonyms: | CCL8, HC14, MCP-2, MCP2, SCYA10, SCYA8 |
| Background: | This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. |
| UniProt Protein Function: | CCL8: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. Belongs to the intercrine beta (chemokine CC) family. |
| UniProt Protein Details: | Protein type:Secreted; Chemokine; Secreted, signal peptide; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: extracellular space Molecular Function:heparin binding; chemokine activity; phospholipase activator activity; protein kinase activity Biological Process: positive regulation of catalytic activity; cellular calcium ion homeostasis; exocytosis; cell-cell signaling; calcium ion transport; response to virus; immune response; chemotaxis; inflammatory response; signal transduction; protein amino acid phosphorylation |
| NCBI Summary: | This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P80075 |
| NCBI GenInfo Identifier: | 2506280 |
| NCBI Gene ID: | 6355 |
| NCBI Accession: | P80075.2 |
| UniProt Secondary Accession: | P80075,P78388, A0AV77, |
| UniProt Related Accession: | P80075 |
| Molecular Weight: | 11,246 Da |
| NCBI Full Name: | C-C motif chemokine 8 |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 8 |
| NCBI Official Symbol: | CCL8 |
| NCBI Official Synonym Symbols: | HC14; MCP2; MCP-2; SCYA8; SCYA10 |
| NCBI Protein Information: | C-C motif chemokine 8; small-inducible cytokine A8; monocyte chemotactic protein 2; monocyte chemoattractant protein 2; small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2) |
| UniProt Protein Name: | C-C motif chemokine 8 |
| UniProt Synonym Protein Names: | HC14; Monocyte chemoattractant protein 2; Monocyte chemotactic protein 2; MCP-2; Small-inducible cytokine A8Cleaved into the following chain:MCP-2(6-76) |
| Protein Family: | C-C motif chemokine |
| UniProt Gene Name: | CCL8 |
| UniProt Entry Name: | CCL8_HUMAN |
 | Immunohistochemistry of paraffin-embedded human liver using CCL8 antibody (CAB6977) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using CCL8 antibody (CAB6977) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using CCL8 antibody (CAB6977) at dilution of 1:100 (40x lens). |
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