Cell Biology Antibodies 7
Anti-CCL20 Antibody (CAB1756)
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- SKU:
- CAB1756
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CCL20 Antibody |
| Antibody SKU: | CAB1756 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-95 of human CCL20 (NP_001123518.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | K-562, LO2, A-549, BxPC-3 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-95 of human CCL20 (NP_001123518.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MCCT KSLL LAAL MSVL LLHL CGES EASN FDCC LGYT DRIL HPKF IVGF TRQL ANEG CDIN AIIF HTKK KLSV CANP KQTW VKYI VRLL SKKV KNM |
| Gene ID: | 6364 |
| Uniprot: | P78556 |
| Cellular Location: | Secreted |
| Calculated MW: | 10kDa |
| Observed MW: | 15kDa |
| Synonyms: | CCL20, CKb4, Exodus, LARC, MIP-3-alpha, MIP-3a, MIP3A, SCYA20, ST38 |
| Background: | This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CCL20: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213. Belongs to the intercrine beta (chemokine CC) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Chemokine; Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q36.3 Cellular Component: extracellular space; extracellular region Molecular Function:protein binding; chemokine activity Biological Process: cell-cell signaling; wound healing; defense response to bacterium; immune response; chemotaxis; inflammatory response; signal transduction; positive regulation of interleukin-1 alpha biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process |
| NCBI Summary: | This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P78556 |
| NCBI GenInfo Identifier: | 2829668 |
| NCBI Gene ID: | 6364 |
| NCBI Accession: | P78556.1 |
| UniProt Secondary Accession: | P78556,Q53S51, Q99664, |
| UniProt Related Accession: | P78556 |
| Molecular Weight: | 10,691 Da |
| NCBI Full Name: | C-C motif chemokine 20 |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 20 |
| NCBI Official Symbol: | CCL20 |
| NCBI Official Synonym Symbols: | CKb4; LARC; ST38; MIP3A; Exodus; MIP-3a; SCYA20; MIP-3-alpha |
| NCBI Protein Information: | C-C motif chemokine 20; CC chemokine LARC; beta chemokine exodus-1; small-inducible cytokine A20; macrophage inflammatory protein 3 alpha; liver and activation-regulated chemokine; small inducible cytokine subfamily A (Cys-Cys), member 20 |
| UniProt Protein Name: | C-C motif chemokine 20 |
| UniProt Synonym Protein Names: | Beta-chemokine exodus-1; CC chemokine LARC; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; Small-inducible cytokine A20Cleaved into the following 3 chains:CCL20(1-67); CCL20(1-64); CCL20(2-70) |
| Protein Family: | C-C motif chemokine |
| UniProt Gene Name: | CCL20 |
| UniProt Entry Name: | CCL20_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CCL20 antibody (CAB1756) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5min. |
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