KO Validated Antibodies 2

Anti-CCDC6 Antibody (CAB19901)[KO Validated]

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SKU:
CAB19901
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CCDC6 Antibody [KO Validated]
Antibody SKU:CAB19901
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human CCDC6.
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa
Immunogen:Recombinant protein of human CCDC6.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8030
Uniprot:Q16204
Cellular Location:Cytoplasm, cytoskeleton
Calculated MW:53kDa
Observed MW:68KDa
Anti-CCDC6 Antibody [KO Validated] (CAB19901)Western blot analysis of extracts from normal (control) and CCDC6 knockout (KO) HeLa cells, using CCDC6 antibody (CAB19901) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Synonyms:CCDC6, D10S170, H4, PTC, TPC, TST1
Background:This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.
UniProt Protein Function:CCDC6: Defects in CCDC6 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving CCDC6 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.
UniProt Protein Details:

Protein type:Cytoskeletal; Oncoprotein; Apoptosis

Chromosomal Location of Human Ortholog: 10q21

Cellular Component: cytoplasm

Molecular Function:protein binding; structural constituent of cytoskeleton

Disease: Thyroid Carcinoma, Papillary

NCBI Summary:This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]
UniProt Code:Q16204
NCBI GenInfo Identifier:292494979
NCBI Gene ID:8030
NCBI Accession:Q16204.2
UniProt Secondary Accession:Q16204,Q15250, Q6GSG7,
UniProt Related Accession:Q16204
Molecular Weight:53,291 Da
NCBI Full Name:Coiled-coil domain-containing protein 6
NCBI Synonym Full Names:coiled-coil domain containing 6
NCBI Official Symbol:CCDC6  
NCBI Official Synonym Symbols:H4; PTC; TPC; TST1; D10S170  
NCBI Protein Information:coiled-coil domain-containing protein 6
UniProt Protein Name:Coiled-coil domain-containing protein 6
UniProt Synonym Protein Names:Papillary thyroid carcinoma-encoded protein; Protein H4
Protein Family:Coiled-coil domain-containing protein
UniProt Gene Name:CCDC6  
UniProt Entry Name:CCDC6_HUMAN
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