Cell Biology Antibodies 10

Anti-CCBL1 Antibody (CAB6542)

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SKU:
CAB6542
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CCBL1 Antibody
Antibody SKU:CAB6542
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CCBL1 (NP_001116144.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Raji, HeLa, SW620, Mouse liver, Mouse kidney, Mouse heart, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CCBL1 (NP_001116144.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAKQ LQAR RLDG IDYN PWVE FVKL ASEH DVVN LGQG FPDF PPPD FAVE AFQH AVSG DFML NQYT KTFV IIIE PFFD CYEP MTMM AGGR PVFV SLKP GPIQ NGEL GSSS NWQL DPME LAGK FTSR TKAL VLNT PNNP LGKV FSRE ELEL VASL CQQH DVVC ITDE VYQW MVYD GHQH ISIA SLPG MWER TLTI GSAG KTFS ATGW KVGW VLGP DHIM KHLR TVHQ NSVF HCPT QSQA AVAE SFER EQLL FRQP SSYF VQFP QAMQ RCRD HM
Gene ID:883
Uniprot:Q16773
Cellular Location:Cytoplasm
Calculated MW:27kDa/42kDa/47kDa
Observed MW:48kDa
Synonyms:KYAT1, CCBL1, GTK, KAT1, KATI
Background:This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene.
UniProt Protein Function:CCBL1: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 4.4.1.13; Lyase; EC 2.6.1.7; Transferase; EC 2.6.1.64

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function:glutamine-pyruvate transaminase activity; kynurenine-oxoglutarate transaminase activity; phenylalanine(histidine) transaminase activity; protein binding; protein homodimerization activity; transaminase activity

Biological Process: amino acid biosynthetic process; amino acid derivative metabolic process; L-phenylalanine catabolic process; tryptophan catabolic process

NCBI Summary:This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q16773
NCBI GenInfo Identifier:46396284
NCBI Gene ID:883
NCBI Accession:Q16773.1
UniProt Secondary Accession:Q16773,Q5T275, Q8N191,
UniProt Related Accession:Q16773
Molecular Weight:27,420 Da
NCBI Full Name:Kynurenine--oxoglutarate transaminase 1
NCBI Synonym Full Names:kynurenine aminotransferase 1
NCBI Official Symbol:KYAT1  
NCBI Official Synonym Symbols:GTK; KAT1; KATI; CCBL1  
NCBI Protein Information:kynurenine--oxoglutarate transaminase 1
UniProt Protein Name:Kynurenine--oxoglutarate transaminase 1
UniProt Synonym Protein Names:Cysteine-S-conjugate beta-lyase (EC:4.4.1.13); Glutamine transaminase K; GTK; Glutamine--phenylpyruvate transaminase (EC:2.6.1.64); Kynurenine aminotransferase 1
UniProt Gene Name:KYAT1  
UniProt Entry Name:KAT1_HUMAN
Anti-CCBL1 Antibody (CAB6542)Western blot analysis of extracts of various cell lines, using CCBL1 Antibody (CAB6542) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-CCBL1 Antibody (CAB6542)Immunohistochemistry of paraffin-embedded mouse liver using CCBL1 antibody (CAB6542) at dilution of 1:100 (40x lens).
Anti-CCBL1 Antibody (CAB6542)Immunohistochemistry of paraffin-embedded mouse heart using CCBL1 antibody (CAB6542) at dilution of 1:100 (40x lens).
Anti-CCBL1 Antibody (CAB6542)Immunofluorescence analysis of U2OS cells using CCBL1 antibody (CAB6542). Blue: DAPI for nuclear staining.
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