Epigenetics & Nuclear Signaling Antibodies 3
Anti-CC2D1A Antibody (CAB4800)
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- SKU:
- CAB4800
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CC2D1A
- Synonyms:
- FREUD-1
- Synonyms:
- Freud-1/Aki1
- Synonyms:
- MRT3
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | CC2D1A Rabbit pAb |
| Product Code: | CAB4800 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CC2D1A, FREUD-1, Freud-1/Aki1, MRT3 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CC2D1A (NP_060191.3). |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:1000 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-251MG, SKOV3, 293T, A-549, LO2, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CC2D1A (NP_060191.3). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MHKR KGPP GPPG RGAA AARQ LGLL VDLS PDGL MIPE DGAN DEEL EAEF LALV GGQP PALE KLKG KGPL PMEA IEKM ASLC MRDP DEDE EEGT DEDD LEAD DDLL AELN EVLG EEQK ASET PPPV AQPK PEAP HPGL ETTL QERL ALYQ TA |
| Gene ID: | 54862 |
| Uniprot: | Q6P1N0 |
| Cellular Location: | Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center |
| Calculated MW: | 103kDa/104kDa |
| Observed MW: | 131kDa |
| UniProt Protein Function: | CC2D1A: a transcription factor that binds specifically to the FRE (five repressor element) and represses 5- HT1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of 5- HT1A associated with anxiety and major depression. Mediates HDAC-independent repression of 5- HT1A promoter in neuronal cells. Three alternatively spliced human isoforms have been described. |
| UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 19p13.12 Cellular Component: membrane; cytoplasm; microtubule organizing center; nucleus Molecular Function:signal transducer activity Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; signal transduction Disease: Mental Retardation, Autosomal Recessive 3 |
| NCBI Summary: | This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in a nonsyndromic form of cognitive disability (MRT3). [provided by RefSeq, Jul 2017] |
| UniProt Code: | Q6P1N0 |
| NCBI GenInfo Identifier: | 74737148 |
| NCBI Gene ID: | 54862 |
| NCBI Accession: | Q6P1N0.1 |
| UniProt Related Accession: | Q6P1N0 |
| Molecular Weight: | |
| NCBI Full Name: | Coiled-coil and C2 domain-containing protein 1A |
| NCBI Synonym Full Names: | coiled-coil and C2 domain containing 1A |
| NCBI Official Symbol: | CC2D1A |
| NCBI Official Synonym Symbols: | MRT3; FREUD-1; Freud-1/Aki1 |
| NCBI Protein Information: | coiled-coil and C2 domain-containing protein 1A |
| UniProt Protein Name: | Coiled-coil and C2 domain-containing protein 1A |
| UniProt Synonym Protein Names: | Akt kinase-interacting protein 1; Five prime repressor element under dual repression-binding protein 1; FRE under dual repression-binding protein 1; Freud-1; Putative NF-kappa-B-activating protein 023N |
| UniProt Gene Name: | CC2D1A |
| UniProt Entry Name: | C2D1A_HUMAN |
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